AB17003
Anti-Bim Antibody, internal epitope, pan-Bim isoforms
Chemicon®, from rabbit
Sinonimo/i:
BOD
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About This Item
Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Prodotti consigliati
Origine biologica
rabbit
Livello qualitativo
Forma dell’anticorpo
affinity purified immunoglobulin
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Reattività contro le specie
mouse, human, rat
Produttore/marchio commerciale
Chemicon®
tecniche
western blot: suitable
N° accesso UniProt
Condizioni di spedizione
wet ice
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... TMBIM4(51643)
Specificità
Recognizes pan-Bim isoforms.
Immunogeno
Epitope: internal epitope, pan-Bim isoforms
Synthetic peptide corresponding to amino acids 22-40 of human origin (O′Conneor et al. 1998). The sequence is identical to that of mouse and is different by one amino acid from that of rat.
Applicazioni
Research Category
Apoptosis & Cancer
Apoptosis & Cancer
Research Sub Category
BCL2 & Inhibition
BCL2 & Inhibition
This Anti-Bim Antibody, internal epitope, pan-Bim isoforms is validated for use in WB for the detection of Bim.
Western blot: 1:1000-1:2000
Human K562 cell lysate can be used as a positive control and a 23 kDa band can be detected.
Optimal working dilutions must be determined by end user.
Human K562 cell lysate can be used as a positive control and a 23 kDa band can be detected.
Optimal working dilutions must be determined by end user.
Descrizione del bersaglio
23 kDa
Stato fisico
Format: Purified
ImmunoAffinity Purified
Immunoaffinity Purified immunoglobulin in 20 mM sodium phosphate, 250 mM NaCl, pH. 7.6, with 0.1% sodium azide as a preservative.
Stoccaggio e stabilità
The undiluted antibody solution is stable for approximately 6 months when stored 2–8°C.
Risultati analitici
Control
Skin/Skin Tumor
Skin/Skin Tumor
Altre note
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Note legali
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Raccomandato
N° Catalogo
Descrizione
Determinazione del prezzo
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
The BH3 mimetic ABT-263 synergizes with the MEK1/2 inhibitor selumetinib/AZD6244 to promote BIM-dependent tumour cell death and inhibit acquired resistance.
Sale, MJ; Cook, SJ
The Biochemical Journal null
Induction of apoptosis in plasma cells by B lymphocyte-induced maturation protein-1 knockdown.
Lin, FR; Kuo, HK; Ying, HY; Yang, FH; Lin, KI
Cancer Research null
The BH3-only protein Puma is both necessary and sufficient for neuronal apoptosis induced by DNA damage in sympathetic neurons.
Andreas Wyttenbach, Aviva M Tolkovsky, Andreas Wyttenbach, Aviva M Tolkovsky
Journal of Neurochemistry null
Julia P Huang et al.
Oncology letters, 14(5), 5735-5742 (2017-11-09)
Enhancer of zeste homolog 2 (EZH2), a subunit of polycomb repressive complex 2, is a histone methyl-transferase and is considered to work cooperatively with histone deacetylases (HDACs) in the same protein complex to mediate gene transcription repression by increasing histone
Amphiregulin contributes to the transformed phenotype of human hepatocellular carcinoma cells.
Castillo, J; Erroba, E; Perugorria, MJ; Santamaria, M; Lee, DC; Prieto, J; Avila, MA; Berasain, C
Cancer Research null
Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..
Contatta l'Assistenza Tecnica.