676481

VEGFR Tyrosine Kinase Inhibitor II

The VEGFR Tyrosine Kinase Inhibitor II, also referenced under CAS 269390-69-4, controls the biological activity of VEGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Sinonimo/i: VEGFR Tyrosine Kinase Inhibitor II, N-(4-Chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide, VEGF Receptor Tyrosine Kinase Inhibitor II, VEGFR2 Kinase Inhibitor XVII, VEGFR1 Kinase Inhibitor III
• Formula empirica (notazione di Hill): C₁₉H₁₆ClN₃O
• Numero CAS: 269390-69-4
• Peso molecolare: 337.80
• Codice UNSPSC: 12352200
• NACRES: NA.54

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: white
• Solubilità: DMSO: 5 mg/mL; methanol: soluble
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• InChI: 1S/C19H16ClN3O/c20-15-5-7-16(8-6-15)23-19(24)17-3-1-2-4-18(17)22-13-14-9-11-21-12-10-14/h1-12,22H,13H2,(H,23,24); GGPZCOONYBPZEW-UHFFFAOYSA-N

Descrizione

Descrizione generale

A potent, cell-permeable, reversible, and ATP-competitive inhibitor of the kinase activities of KDR, Flt-1 and c-Kit (IC₅₀ = 20 nM, 180 nM and 240 nM, respectively), and minimally inhibit c-Src and EGF-R activities (IC₅₀ = 7.0 µM and 7.3 µM). Also displays antiangiogenic and antitumor properties. Does not inhibit the activities of CDK-1, c-Met, IGF-1R or PKA (IC₅₀ >10 µM).

A pyridinyl-anthranilamide compound that displays both antiangiogenic and antitumor properties. A potent, cell-permeable, reversible, and ATP-competitive inhibitor of the kinase activities of KDR, Flt-1 and c-Kit (IC₅₀ = 20 nM, 180 nM and 240 nM, respectively), and minimally inhibit c-Src and EGF-R activities (IC₅₀ = 7 µM and 7.3 µM). Further, inactive towards the inhibition of CDK-1, c-Met, IGF-1R and PKA (IC₅₀ >10 µM).

Azioni biochim/fisiol

Cell permeable: yes

Primary Target
Kinase activities of KDR, Flt-1 and c-Kit

Product competes with ATP.

Reversible: yes

Target IC₅₀: 20 nM, 180 nM and 240 nM against kinase activities of KDR, Flt-1 and c-Kit, respectively

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Standard Handling (A)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Altre note

Furet, P., et al. 2003. Bioorg. Med. Chem. Lett.13, 2967.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable