565755

γ-Secretase Inhibitor II

The γ-Secretase Inhibitor II controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

• Sinonimo/i: γ-Secretase Inhibitor II, MW167
• Formula empirica (notazione di Hill): C₃₃H₅₇F₂N₅O₉
• Peso molecolare: 705.83
• Codice UNSPSC: 12352200
• NACRES: NA.54

Proprietà

• Livello qualitativo: 100
• Saggio: ≥95% (HPLC)
• Stato: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze
• Colore: white
• Solubilità: DMSO: 10 mM
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −20°C

Descrizione

Descrizione generale

A cell-permeable, reversible and selective peptidomimetic inhibitor of γ-secretase (IC₅₀ = 13 µM for Aβ). Displays only weak inhibitory activity against calpain II (IC₅₀ = 100 µM in a purified enzyme assay).

Please note that the molecular weight for this compound is batch-specific due to variable water content.

A cell-permeable, reversible and selective peptidomimetic inhibitor of γ-secretase with an IC₅₀ of 13 µM for the inhibition of amyloid β-protein (Aβ) production in β-amyloid precursor protein (APP)-transfected Chinese hamster ovary cells. Displays only weak inhibitory activity against calpain II (IC₅₀ = 100 µM in a purified enzyme assay).

Azioni biochim/fisiol

Cell permeable: yes

Primary Target
γ-secretase

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 13 µM against γ-secretase

Attenzione

Toxicity: Standard Handling (A)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Altre note

Wolfe, M.S., et al. 1999. Biochemistry38, 4720.
Wolfe, M.S., et al. 1998. J. Med. Chem. 41, 6.
Citron, M., et al. 1996. Proc. Natl. Acad. Sci. USA93, 13170.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable