506600

Pamidronate, Disodium Salt

A potent and specific inhibitor of bone resorption that does not cause any significant detrimental effect on bone growth and mineralization at concentrations used.

• Sinonimo/i: Pamidronate, Disodium Salt, 3-Amino-1-hydroxypropylidene-bisphosphonic Acid, 2Na, Pentahydrate
• Formula empirica (notazione di Hill): C₃H₉NO₇P₂ · 2Na · 5H₂O
• Numero CAS: 109552-15-0
• Peso molecolare: 369.11
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; desiccated (hygroscopic)
• Colore: white
• Solubilità: water: 10 mg/mL
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −20°C
• InChI: 1S/C3H11NO7P2.2Na.5H2O/c4-2-1-3(5,12(6,7)8)13(9,10)11;;;;;;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;;5*1H2/q;2*+1;;;;;/p-2; CZYWHNTUXNGDGR-UHFFFAOYSA-L

Descrizione

Descrizione generale

A calcium metabolism regulator. A potent and specific inhibitor of bone resorption at doses devoid of any significant detrimental effect on bone growth and mineralization. Effective in a variety of conditions characterized by pathologically enhanced bone turnover, including Paget′s disease, hypercalcemia of malignancy, osteolytic bone metastasis, and steroid-induced cell death in vitro. Provided in a hydrated form containing five molecules of water.

A potent and specific inhibitor of bone resorption that does not cause any significant detrimental effect on bone growth and mineralization at concentrations used. Effective in a variety of conditions characterized by pathologically enhanced bone turnover, including Paget’s disease, hypercalcaemia of malignancy, osteolytic bone metastasis, steroid-induced osteoporosis, and idiopathic osteoporosis. Inhibits breast cancer cell growth by inducing cell death in vitro. Provided in hydrated form, contains five molecules of water.

Azioni biochim/fisiol

Cell permeable: no

Primary Target
Inhibitor of bone resorption

Product does not compete with ATP.

Reversible: no

Attenzione

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Ricostituzione

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.

Altre note

Fromigue, O., et al. 2000. J. Bone Miner. Res.15, 2211.
Fitton, A., and McTravish, D. 1991. Drugs41, 289.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302,H319
• Consigli di prudenza: P264 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313 - P501
• Classi di pericolo: Acute Tox. 4 Oral - Eye Irrit. 2
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable