5.04914

CNQX

• Sinonimo/i: CNQX, 6-Cyano-7-nitroquinoxaline-2,3-dione, 6-Cyano-2,3-dihydroxy-7-nitro-quinoxaline
• Formula empirica (notazione di Hill): C₉H₄N₄O₄
• Numero CAS: 115066-14-3
• Peso molecolare: 232.15
• Numero MDL: MFCD00069232
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Livello qualitativo: 100
• Stato: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: off-white to yellow
• Solubilità: DMSO: 25 mg/mL
• Temperatura di conservazione: 2-8°C
• InChI: 1S/C9H4N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H,(H,11,14)(H,12,15); RPXVIAFEQBNEAX-UHFFFAOYSA-N

Descrizione

Descrizione generale

A potent and competitive antagonist for AMPA/kainate receptors (K_i = 0.6 - 2.11 µM for GluA1-4 and K_i = 1.3-5.3 µM for different subtypes of Kainate receptors) and a negative allosteric modulator at NMDA receptor glycine binding site. Widely used for assessing the functional roles of neurotransmission mediated by glutamate receptors in both normal and abnormal brain functions.

A potent and competitive antagonist for AMPA/kainate receptors (K_i = 0.6 - 2.11 µM for GluA1-4 and K_i = 1.3-5.3 µM for different subtypes of Kainate receptors) and a negative allosteric modulator at NMDA receptor glycine binding site. Widely used for assessing the functional roles of neurotransmission mediated by glutamate receptors in both normal and abnormal brain functions.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Azioni biochim/fisiol

Secondary Target
Kainate

Target K_i: 0.6 – 2.11 →M for GluA1 – 4 and Ki

Attenzione

Toxicity: Standard Handling (A)

Altre note

Lee, S., et al. 2010. J. Neurophysiol.103, 1728.
King, A., et al. 1992. Br. J. Pharmacol.107, 375.
Long, S. et al. 1990. Br. J. Pharmacol.100, 850.Harris, K., et al. 1989. Brain Res.5, 185Honore, T., et al. 1988. Science.241, 701.Birch, P., et al. 1988. Eur. J. Pharmacol.156, 177.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable