5.05986

SR 95531

≥98% (HPLC), solid, GABAA receptor antagonist, Calbiochem^®

• Sinonimo/i: SR95531 (Gabazine), GABA _A Receptor Antagonist, SR-95531, Gabazine, SR95531, SR 95531, GABA_A Receptor Antagonist, SR-95531, Gabazine, SR95531, SR 95531
• Formula empirica (notazione di Hill): C₁₅H₁₇N₃O₃ · xHBr
• Numero CAS: 104104-50-9
• Peso molecolare: 287.31 (free base basis)
• Numero MDL: MFCD00055135
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Nome del prodotto: SR95531 (Gabazine),
• Saggio: ≥98% (HPLC)
• Livello qualitativo: 100
• Stato: solid
• Potenza: 440 nM IC₅₀
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: white
• Solubilità: water: 25 mM
• Temperatura di conservazione: 2-8°C
• InChI: 1S/C15H17N3O3.BrH/c1-21-12-6-4-11(5-7-12)13-8-9-14(16)18(17-13)10-2-3-15(19)20;/h4-9,16H,2-3,10H2,1H3,(H,19,20);1H; GFZHNFOGCMEYTA-UHFFFAOYSA-N

Descrizione

Descrizione generale

A selective, competitive antagonist of GABA_A receptor (IC₅₀ = 440 nM) that does not affect pentobarbitone or etomidate- induced currents even at high concentrations (~100 µM). Also shown to block glycine receptors, but with low affinity (K_b = 190 µM).

A selective, competitive antagonist of GABA_A receptor (IC₅₀ = 440 nM) that does not affect pentobarbitone or etomidate- induced currents even at high concentrations (~100 mM). Also shown to block glycine receptors, but with low affinity (K_b = 190 mM).

Azioni biochim/fisiol

Primary Target
GABA_A

Attenzione

Toxicity: Standard Handling (A)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Altre note

Muroi, Y., et al. 2009. Biophys. J.96, 499.
Beato, M., et al. 2007. J. Physiol.580, 171.
Uchida, I., et al. 1996. Eur. J. Pharmacol.307, 89.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable