442630-M

GMBS

• Sinonimo/i: GMBS, N-γ-Maleimidobutyryloxysuccinimide
• Formula empirica (notazione di Hill): C₁₂H₁₂N₂O₆
• Numero CAS: 80307-12-6
• Peso molecolare: 280.23
• Numero MDL: MFCD00036817
• Codice UNSPSC: 12161500
• NACRES: NA.24

Proprietà

• Saggio: ≥90% (HPLC)
• Livello qualitativo: 100
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze
• Temperatura di conservazione: −20°C
• InChI: 1S/C12H12N2O6/c15-8-3-4-9(16)13(8)7-1-2-12(19)20-14-10(17)5-6-11(14)18/h3-4H,1-2,5-7H2; PVGATNRYUYNBHO-UHFFFAOYSA-N

Descrizione

Descrizione generale

Heterobifunctional reagent useful for preparation of conjugates such as secondary antibodies and β-galactosidase for EIA procedures or for immobilizing enzymes on solid supports.

N-γ-maleimidobutyryloxysuccinimide ester (GMBS) is an aliphatic crosslinker for immunotoxins (IT).(1) It is used for the generation of conjugated Poly-γ-D-glutamic acid.

Applicazioni

GMBS is suitable for use:

• as a hetero-bifunctional cross-linking reagent for the immobilization of neural adhesion molecule L1 onto silicon dioxide surface
• for the crosslinking of biochips with functionalized gold nanoparticles
• for coating salinized capillary tube prior to neutravidin treatment in biosensor sandwich immunoassay

Attenzione

Toxicity: Irritant (B)

Ricostituzione

Reconstitute to 10 mg/ml in tetrahydrofuran or DMSO. Add 1 ml of this stock solution dropwise, with stirring, to 10 ml of 20 mM phosphate buffer.

Altre note

Rusin, K.M., et al. 1992. Biosens. Bioelectron. 7, 367.
Kitagawa, T., et al. 1983. J. Biochem. 94, 1160.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable