353905

Glutathione Monoethyl Ester

>90% (TLC), solid, GSH-MEE transport, Calbiochem^®

• Sinonimo/i: Glutathione Monoethyl Ester, γ-GCE, L-γ-Glutamyl-L-cysteinyl Ethyl Glycinate, GSH-MEE
• Formula empirica (notazione di Hill): C₁₂H₂₁N₃O₆S
• Numero CAS: 118421-50-4
• Peso molecolare: 335.38
• Codice UNSPSC: 12352209
• NACRES: NA.77

Proprietà

• product name: Glutathione Monoethyl Ester, Cell-permeable derivative of glutathione (GSH) that undergoes hydrolysis by intracellular esterases to release GSH.
• Livello qualitativo: 100
• Saggio: >90% (TLC)
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; desiccated (hygroscopic)
• Colore: white
• Solubilità: water: 50 mg/mL
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −20°C
• InChI: 1S/C12H21N3O6S/c1-2-21-10(17)5-14-11(18)8(6-22)15-9(16)4-3-7(13)12(19)20/h7-8,22H,2-6,13H2,1H3,(H,14,18)(H,15,16)(H,19,20)/t7-,8-/m0/s1; JKRODHBGNBKZLE-YUMQZZPRSA-N

Descrizione

Descrizione generale

Cell-permeable derivative of glutathione (GSH) that undergoes hydrolysis by intracellular esterases thereby increasing intracellular GSH concentration in many tissues and cell types. Effective transport of GSH-MEE has been used to protect cells against radiation damage, oxidants and various toxic compounds including heavy metals. A protective agent against cellular damage, such as cataracts and mitochondrial degeneration.

Cell-permeable derivative of glutathione (GSH) that undergoes hydrolysis by intracellular esterases to release GSH. Effective transport of GSH-MEE has been used to protect cells against damage from radiation, oxidants, and various toxic compounds including heavy metals. A protective agent against cellular damage such as in cataracts and mitochondrial degeneration.

Azioni biochim/fisiol

Cell permeable: no

Primary Target
Effective transport of GSH-MEE

Product does not compete with ATP.

Reversible: no

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Standard Handling (A)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Unstable in solution; reconstitute just prior to use.

Altre note

Grattagliano, I., et al. 1995. J. Pharmacol. Exp. Ther. 272, 484.
Martensson, J., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 317.
Anderson, M.E., and Meister, A. 1989. Anal. Biochem. 183, 16.
Anderson, M.E., et al. 1985. Arch. Biochem. Biophys. 239, 538.
Wellner, V.P., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 4732.
Puri, R.N., and Meister, A. 1983. Proc. Natl. Acad. Sci. USA 80, 5258.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable