207001

Calcineurin Autoinhibitory Peptide, Cell-permeable

The Calcineurin Autoinhibitory Peptide, Cell-permeable controls the biological activity of Mn2+-stimulated calcineurin activity. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Sinonimo/i: Calcineurin Autoinhibitory Peptide, Cell-permeable, 11R-CaN-AID, Ac-RRRRRRRRRRRGGGRMAPPRRDAMPSDA-NH₂
• Formula empirica (notazione di Hill): C₁₃₇H₂₅₁N₇₁O₃₄S₂
• Peso molecolare: 3501.04
• Codice UNSPSC: 12352202
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: lyophilized solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; desiccated (hygroscopic); protect from light
• Colore: white
• Solubilità: water: 1 mg/mL
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C

Descrizione

Descrizione generale

A cell-permeable peptide that consists of the calcineurin (CaN) autoinhibitory domain (AID) fused to a poly-arginine-based protein transduction doamin (11R) and acts as an inhibitor of CaN phosphatase activity. Reported to block CaN-dependent NFAT nuclear translocation and NFAT promoter activity in neurons. Also reported to protect neuronal cells from glutamate-induced cell death.

A cell-permeable peptide that is composed of the calcineurin (CaN) autoinhibitory domain (AID) fused to a poly-arginine-based protein transduction domain (11R) and acts as an inhibitor of CaN phosphatase activity. Blocks CaN-dependent NFAT nuclear translocation and NFAT promoter activity in neurons. Protects neuronal cells from glutamate-induced cell death.

Azioni biochim/fisiol

Cell permeable: yes

Primary Target
Blocks CaN-dependent NFAT nuclear translocation

Product does not compete with ATP.

Reversible: no

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Carcinogenic / Teratogenic (D)

Sequenza

Ac-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Gly-Gly-Arg-Met-Ala-Pro-Pro-Arg-Arg-Asp-Ala-Met-Pro-Ser-Asp-Ala-NH₂

Altre note

Terada, H., et al. 2003. J. Neurochem.87, 1145.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable