126850

α₁-PDX, Human, Recombinant, E. coli

Recombinant protein derived from the bioengineered human α1-antitrypsin gene fused to a His•Tag sequence and a FLAG-tag.

• Sinonimo/i: α₁-Antitrypsin Portland
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥80% (SDS-PAGE)
• Forma fisica: lyophilized solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: do not freeze
• Solubilità: water: 2.5 mg/mL
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: 2-8°C

Descrizione

Descrizione generale

Recombinant protein derived from the bioengineered human α1-antitrypsin gene fused to a His·Tag and a FLAG·Tag. Contains a minimal furin consensus sequence, RXXR, that effectively blocks the furin-dependent processing of protein precursors (K_i = 600 pM). α1-PDX can be used in extracellular applications to block the processing of furin substrates. α1-PDX has been shown to inhibit the processing of biologically significant proteins including viral envelope glycoproteins, bacterial toxins, receptors, and growth factors.

Recombinant protein derived from the bioengineered human α₁-antitrypsin gene fused to a His•Tag sequence and a FLAG-tag. Contains a minimal furin consensus sequence, RXXR, that effectively blocks the furin-dependent processing of protein precursors (K_i = 600 pM). Extracellular application of α₁-PDX can be used to inhibit the processing of biologically significant proteins including viral envelope glycoproteins, bacterial toxins, receptors, and growth factors. Useful for in vivo and in vitro furin inhibition assays.

Azioni biochim/fisiol

Cell permeable: no

Primary Target
Furin-dependent processing of protein precursors

Product does not compete with ATP.

Reversible: no

Target K_i: 600 pM against furin-dependent processing of protein precursors

Confezionamento

Please refer to vial label for lot-specific concentration.

Attenzione

Toxicity: Standard Handling (A)

Stato fisico

Lyophilized from PBS.

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Altre note

Bassi, D.E., et al. 2001. Proc. Natl. Acad. Sci. USA98, 10326.
Jean, F., et al. 2000. Proc. Natl. Acad. Sci. USA97, 2864.
Jean, F., et al. 1998. Proc. Natl. Acad. Sci. USA95, 7293.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable