09-454
Anti-Dock2 Antibody
from rabbit, purified by affinity chromatography
Sinonimo/i:
dedicator of cyto-kinesis 2, dedicator of cytokinesis 2
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About This Item
Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Prodotti consigliati
Origine biologica
rabbit
Livello qualitativo
Forma dell’anticorpo
affinity isolated antibody
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Purificato mediante
affinity chromatography
Reattività contro le specie
mouse, human, primate, horse
tecniche
immunohistochemistry: suitable
western blot: suitable
Isotipo
IgG
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... DOCK2(1794)
Descrizione generale
Dock2 (Dedicator of cytokinesis 2), is a large protein involved in intracellular signaling networks and a member of the DOCK-A subfamily which function as activators of small G proteins. Dock2 specifically activates isoforms of the small G protein Rac and appears to be expressed specifically in leukocytes. These cells express both Rac1 and Rac2 and Dock2 has been shown to bind and promote nucleotide exchange on both of these isoforms. (Nishihara, 1999)
Specificità
09-454 recognizes mouse DOCK2.
Predicted to cross react with human, equine, and primate, based on 93% sequence homology (13/14 aa). The sequence is 85.7% homologous in rat. Reactivity with other species has not been tested.
Immunogeno
Epitope: Internal region
KLH-conjugated synthetic peptide near amino acid 1730, within the internal region of mouse DOCK2.
Applicazioni
Research Category
Cell Structure
Cell Structure
Research Sub Category
Cytoskeleton
Cytoskeleton
Western Blotting; Anti-Dock2 Antibody is an antibody against Dock2 for use in WB
Immunohistchemistry (Frozen sections): A representative lot of this antibody dectected DOCK2 in mouse and human brain frozen tissue sections (Cimino, PJ et al. (2009). Am. J. Pathol. 175(4); 1622-1630)
Immunohistchemistry (Frozen sections): A representative lot of this antibody dectected DOCK2 in mouse and human brain frozen tissue sections (Cimino, PJ et al. (2009). Am. J. Pathol. 175(4); 1622-1630)
Qualità
Evaluated by Western blot on mouse spleen lysate 0.5 μg/mL of Anti-DOCK2 at 1 mg/mL.
Descrizione del bersaglio
180 kDa
Stato fisico
Peptide affinity purified
Purified in PBS containing 0.05% NaN3.
Stoccaggio e stabilità
Maintain at 2-8°C for up to 1 year from date of receipt.
Risultati analitici
Control
Mouse spleen lysate
Mouse spleen lysate
Altre note
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
12 - Non Combustible Liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
DOCK2 is a microglial specific regulator of central nervous system innate immunity found in normal and Alzheimer's disease brain.
Cimino, PJ; Sokal, I; Leverenz, J; Fukui, Y; Montine, TJ
The American Journal of Pathology null
Addendum: defective Dock2 expression in a subset of ASC-deficient mouse lines.
Sirish K Ippagunta,R K Subbarao Malireddi,Patrick J Shaw,Geoffrey A Neale et al.
Nature Immunology null
Kazuhito Gotoh et al.
Blood, 111(6), 2973-2976 (2008-01-17)
The migratory properties of dendritic cells (DCs) are important for their functions. Although several chemokines and their receptors have been implicated in DC migration, the downstream signaling molecules are largely unknown. Here we show that DOCK2, a hematopoietic cell-specific CDM
César Nombela-Arrieta et al.
The Journal of experimental medicine, 204(3), 497-510 (2007-02-28)
Recent observations using multiphoton intravital microscopy (MP-IVM) have uncovered an unexpectedly high lymphocyte motility within peripheral lymph nodes (PLNs). Lymphocyte-expressed intracellular signaling molecules governing interstitial movement remain largely unknown. Here, we used MP-IVM of murine PLNs to examine interstitial motility
H Nishihara et al.
Biochimica et biophysica acta, 1452(2), 179-187 (1999-11-24)
Human DOCK180, which was originally identified as a major protein bound to the Crk oncogene product, is an archetype of the CDM family of proteins, including Ced-5 of Caenorhabditis elegans and Mbc of Drosophila melanogaster. After DOCK180, at least three
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