07-442-AF488

Anti-trimethyl Histone H3 (Lys9) Antibody, Alexa Fluor^™ 488 Conjugate

0.5 mg/mL, from rabbit

• Sinonimo/i: Histone H3.1t, H3/t, H3t, H3/g
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100
• Coniugato: ALEXA FLUOR^™ 488
• Forma dell’anticorpo: purified antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Reattività contro le specie: human
• Reattività contro le specie (prevista in base all’omologia): chicken (based on 100% sequence homology), rat (based on 100% sequence homology), mouse (based on 100% sequence homology)
• Concentrazione: 0.5 mg/mL
• tecniche: immunocytochemistry: suitable
• N° accesso NCBI: NM_003493
• N° accesso UniProt: Q16695
• Condizioni di spedizione: wet ice
• modifica post-traduzionali bersaglio: trimethylation (Lys9)
• Informazioni sul gene: human ... H3C1(8350) ; mouse ... H3C1(360198) ; rat ... H3C1(679994)

Descrizione

Descrizione generale

Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the ′beads on a string′ structure. Histone proteins are highly post-translationally modified, and Histone H3 is the most extensively modified of the five histones. Histone H3 sequence variants and variable modification states are thought to play a role in the dynamic and long term regulation of genes. Di- and tri-methylation of histone H3 are gene silencing marks, while removal of these marks by the demethylase genes Jmjd1a and Jmjd2c leads to gene activation. This product is a conjugated version of Cat. No. 07-442.

Immunogeno

Linear peptide corresponding to Histone H3 trimethylated at Lys9.

Applicazioni

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Histones

This Anti-trimethyl Histone H3 (Lys9) Antibody, Alexa Fluor^™ 488 Conjugate is validated for use in ICC for the detection of trimethyl Histone H3 (Lys9).

Qualità

Evaluated by Immunocytochemistry in HeLa cell lysate.

Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected trimethyl Histone H3 (Lys9) in HeLa cells.

Alexa Fluor^™ is a registered trademark of Life Technologies.

Descrizione del bersaglio

~17 kDa observed (Refer to Cat. No. 07-442)

Stato fisico

Protein A purified

Purified rabbit conjugate in buffer containing PBS with 15 mg/ml BSA and 0.1% Sodium Azide.

Stoccaggio e stabilità

Stable for 1 year at 2-8°C from date of receipt.

Note legali

ALEXA FLUOR is a trademark of Life Technologies

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable