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Key Documents

07-108

Sigma-Aldrich

Anti-Histone H4 Antibody

Upstate®, from rabbit

Sinonimo/i:

H4 histone family, member A, histone 1, H4a, histone cluster 1, H4a

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About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

Forma dell’anticorpo

purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Reattività contro le specie

Xenopus, mouse, avian, chicken, human, bovine

Produttore/marchio commerciale

Upstate®

tecniche

western blot: suitable

Isotipo

IgG

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

wet ice

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

bovine ... H4C1(617905)
frog ... H4C1(549623)
human ... H4C1(8359)
mouse ... H4C1(326619)

Descrizione generale

Histone H4 is one of the 5 main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N terminal tail H4 is involved with the structure of the nucleosomes of the ′beads on a string′ structure.

Specificità

Broad species cross-reactivity expected.
Recognizes Histone H4, Mr 10 kDa.

Immunogeno

Calf thymus histone H4.

Applicazioni

Research Category
Epigenetics & Nuclear Function
Research Sub Category
Histones
Use Anti-Histone H4 Antibody (Rabbit Polyclonal Antibody) validated in WB to detect Histone H4 also known as Histone H4.

Qualità

Routinely evaluated by western blot on acid extracts of HeLa cells treated with sodium butyrate.

Western Blot Analysis:
0.1-0.5 μg/mL of this lot detected Histone H4 in acid extracts of HeLa cells treated with or without 5 mM sodium butyrate. This lot did not cross react with Histone H2A, Histone H2B or Histone H3.

Descrizione del bersaglio

10 kDa

Stato fisico

Format: Purified
Protein A chromatography
Purified rabbit polyclonal IgG in buffer containing 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% Sodium Azide.

Stoccaggio e stabilità

Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.

Risultati analitici

Control
HeLa cell extract.

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Note legali

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Raccomandato

Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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S L Gilbert et al.
The Journal of biological chemistry, 275(47), 36491-36494 (2000-09-28)
Microscopy studies have shown that XIST RNA colocalizes with the inactive X chromosome (Xi). However, the molecular basis for this colocalization is unknown. Here we provide two lines of evidence from chromatin immunoprecipitation experiments that XIST RNA physically associates with
Regulation of chemokine gene expression by hypoxia via cooperative activation of NF-kappaB and histone deacetylase.
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Acetylation of C-terminal lysine residues in the p53 tumor suppressor is associated with increased stability and transcription factor activity. The function, protein level, and acetylation of p53 are downregulated by mdm2, which in its turn is inhibited by the p14(ARF)
Histone deacetylases and ASYMMETRIC LEAVES2 are involved in the establishment of polarity in leaves of Arabidopsis.
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