05-23-0600

Substance P

Neuropeptide found in high concentrations in the gut.

• Sinonimo/i: Substance P, Neurokinin P, RPKPQQFFGLM, SP
• Formula empirica (notazione di Hill): C₆₃H₉₈N₁₈O₁₃S
• Numero CAS: 33507-63-0
• Peso molecolare: 1347.63
• Codice UNSPSC: 12352202
• NACRES: NA.51

Proprietà

• Livello qualitativo: 100
• Saggio: ≥96% (HPLC)
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; desiccated (hygroscopic)
• Colore: white
• Solubilità: 5% acetic acid: 1 mg/mL
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −20°C
• InChI: 1S/C63H98N18O13S/c1-37(2)33-45(57(89)74-41(53(68)85)27-32-95-3)73-52(84)36-72-54(86)46(34-38-15-6-4-7-16-38)78-58(90)47(35-39-17-8-5-9-18-39)79-56(88)42(23-25-50(66)82)75-55(87)43(24-26-51(67)83)76-59(91)49-22-14-31-81(49)62(94)44(20-10-11-28-64)77-60(92)48-21-13-30-80(48)61(93)40(65)19-12-29-71-63(69)70/h4-9,15-18,37,40-49H,10-14,19-36,64-65H2,1-3H3,(H2,66,82)(H2,67,83)(H2,68,85)(H,72,86)(H,73,84)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,90)(H,79,88)(H4,69,70,71)/t40-,41-,42-,43-,44-,45-,46-,47-,48-,49-/m0/s1; ADNPLDHMAVUMIW-CUZNLEPHSA-N

Descrizione

Descrizione generale

Substance P (SP) is an 11-amino acid neuropeptide belonging to the tachykinin (TAC) family of neuropeptides. It is encoded by the TAC1 gene in the central nervous system (CNS), the peripheral nervous system, and immune cells. Moreover, it serves essential functions in inflammation, angiogenesis, and wound healing. It is also found in high concentrations in the gut. When released from afferent nerves, it causes a neurogenic inflammatory response, including mast cell degranulation. It is known to induce Ca2+ mobilization and reported to activate Goα, Gq/11α, and Gsα subunits in CHO cells via activation of substance P receptors. Also reported to induce superoxide production in neutrophils.

Applicazioni

Substance P (SP) has been used to enhance the lipid accumulation in 3T3‑L1 cells as they undergo differentiation into adipocytes in the presence of elevated glucose levels.

Azioni biochim/fisiol

Cell permeable: no

Primary Target
Substance P receptors

Product does not compete with ATP.

Reversible: no

Confezionamento

Yes

Attenzione

Toxicity: Standard Handling (A)

Sequenza

H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH₂

Stato fisico

Supplied as a trifluoroacetate salt.

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Altre note

Roush, E.D., and Kwatra, M.M. 1998. FEBS Lett. 428, 291.
Chiwakata, C.B., et al. 1996. Infect. Immun. 64, 5106.
Tanabe, T., et al. 1996. Eur. J. Pharmacol. 299, 187.
Heath, M.J., et al. 1994. J. Neurophysiol. 72, 1192.
Zhu, J., et al. 1994. Eur. J. Pharmacol. 268, 279.
Garland, A.M., et al. 1993. Soc. Neurosci. 19, Abstract 104.6.
Wei, J.Y., et al. 1993. Soc. Neurosci. 19, Abstract 136.14.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable