Passa al contenuto
Merck
Tutte le immagini(2)

Documenti fondamentali

810174P

Avanti

16:0-12:0 NBD PA

Avanti Research™ - A Croda Brand 810174P, powder

Sinonimo/i:

1-palmitoyl-2-{12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl}-sn-glycero-3-phosphate (ammonium salt)

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(2)

About This Item

Formula empirica (notazione di Hill):
C37H66N5O11P
Numero CAS:
474942-96-6
Peso molecolare:
787.92
Numero MDL:
MFCD00467278
Codice UNSPSC:
12352211
NACRES:
NA.25

Saggio

>99% (TLC)

Stato

powder

Confezionamento

pkg of 1 × 1 mg (810174P-1mg)

Produttore/marchio commerciale

Avanti Research™ - A Croda Brand 810174P

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Descrizione generale

Phosphatidic acid (PA) is a simple anionic cellular glycerophospholipid possessing a phosphomonoester polar head group and two long hydrophobic acyl chains. 7-nitro-2-1,3-benzoxadiazol-4-yl (NBD) PA is a fluorophore labeled phospholipid having 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) at the sn-2 fatty acid of PA.

Applicazioni

16:0-12:0 NBD PA or 1-palmitoyl-2-{12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl}-sn-glycero-3-phosphate (ammonium salt) is suitable:
  • to incubate cells for the imaging of lyso phosphatidylcholine (PC) in P. falciparum live cells
  • as a component of separation buffer for the separation of phosphoinositides and sphingolipids in the microchip devices
  • in cytidine diphosphate diacylglycerol (CDP-DAG) synthase activity assay

Azioni biochim/fisiol

Phosphatidic acid (PA) influences membrane fusion and membrane fission events and membrane curvature. It acts as a signaling molecule for various cellular processes including membrane trafficking and sperm hyper-activation.

Confezionamento

5 mL Amber Glass Screw Cap Vial (810174P-1mg)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Codice della classe di stoccaggio

11 - Combustible Solids

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documenti section.

Se ti serve aiuto, non esitare a contattarci Servizio Clienti

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

Yasushi Tamura et al.
Cell metabolism, 17(5), 709-718 (2013-04-30)
CDP-diacylglycerol (CDP-DAG) is central to the phospholipid biosynthesis pathways in cells. A prevailing view is that only one CDP-DAG synthase named Cds1 is present in both the endoplasmic reticulum (ER) and mitochondrial inner membrane (IM) and mediates generation of CDP-DAG
Tam41 is a CDP-diacylglycerol synthase required for cardiolipin biosynthesis in mitochondria
Tamura Y, et al.
Cell Metabolism, 17(5), 709-718 (2013)
Phosphatidic acid binding proteins display differential binding as a function of membrane curvature stress and chemical properties
Putta P, et al.
Biochimica et Biophysica Acta, 1858(11), 2709-2716 (2016)
Phosphatidic acid in membrane rearrangements
Zhukovsky MA, et al.
Febs Letters, 593(17), 2428-2451 (2019)
Mikhail A Zhukovsky et al.
FEBS letters, 593(17), 2428-2451 (2019-08-01)
Phosphatidic acid (PA) is the simplest cellular glycerophospholipid characterized by unique biophysical properties: a small headgroup; negative charge; and a phosphomonoester group. Upon interaction with lysine or arginine, PA charge increases from -1 to -2 and this change stabilizes protein-lipid
Visualizza tutti i documenti correlati

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.