700136P
Avanti
7α,27-dihydroxycholesterol-d6
Avanti Research™ - A Croda Brand 700136P, powder
Sinonimo/i:
7α,27-dihydroxycholesterol-d6
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About This Item
Formula empirica (notazione di Hill):
C27H40D6O3
Numero CAS:
Peso molecolare:
424.69
Codice UNSPSC:
12352211
NACRES:
NA.25
Prodotti consigliati
Saggio
>99% (TLC)
Forma fisica
powder
Confezionamento
pkg of 1 × 1 mg (700136P-1mg)
Produttore/marchio commerciale
Avanti Research™ - A Croda Brand 700136P
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
Descrizione generale
7α,27-dihydroxycholesterol (7α,27-di-OHC) is synthesized by the hydroxylation of 27-hydroxycholesterol (27-OHC). It is an oxysterol with side chains oxidized and is a structural isomer of 7α,25-dihydroxycholesterol. 7α,27-dihydroxycholesterol-d6 is a deuterated derivative of 7α,27-di-OHC.
Applicazioni
7α,27-dihydroxycholesterol-d6 has been used as a deuterated internal standard in liquid chromatography electrospray ionization tandem mass spectrometric (LC/ESI-MS/MS) for human plasma oxysterol analysis.
Azioni biochim/fisiol
7α,27-dihydroxycholesterol (7α,27-di-OHC) is a ligand for Epstein-Barr virus-induced gene 2 (EBI2). 7α27-di-OHC is implicated in neurological disease, Smith-Lemli-Opitz syndrome, obesity metabolic syndrome and diabetes by lipidomics analysis of human cerebrospinal fluid (CSF) samples. The levels of 7α,27-di-OHC decreases in lipopolysaccharide activation.
Confezionamento
5 mL Amber Glass Screw Cap Vial (700136P-1mg)
Note legali
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Comunemente ordinati con questo prodotto
N° Catalogo
Descrizione
Determinazione del prezzo
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
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Barbara Sottero et al.
Free radical biology & medicine, 144, 55-71 (2019-05-30)
High amounts of cholesterol have been definitely associated with the pathogenesis of several diseases, including metabolic and neurodegenerative disorders, cardiovascular diseases, and cancer. In all these pathologies the exacerbation of pro-oxidant and inflammatory responses is a consistent feature. In this
Valentin Mutemberezi et al.
Journal of neuroinflammation, 15(1), 74-74 (2018-03-11)
Oxysterols are cholesterol derivatives that have been suggested to play a role in inflammatory diseases such as obesity, atherosclerosis, or neuroinflammatory diseases. However, the effect of neuroinflammation on oxysterol levels has only been partially studied so far. We used an
Katharina R Beck et al.
Journal of lipid research, 60(9), 1535-1546 (2019-07-06)
Oxysterols previously were considered intermediates of bile acid and steroid hormone biosynthetic pathways. However, recent research has emphasized the roles of oxysterols in essential physiologic processes and in various diseases. Despite these discoveries, the metabolic pathways leading to the different
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