700019P
Avanti
25-hydroxycholesterol
Avanti Research™ - A Croda Brand
Sinonimo/i:
110816
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About This Item
Formula empirica (notazione di Hill):
C27H46O2
Numero CAS:
Peso molecolare:
402.65
Codice UNSPSC:
12352211
NACRES:
NA.25
Prodotti consigliati
Descrizione
cholest-5-ene-3β,25-diol
Saggio
>99% (TLC)
Stato
powder
Confezionamento
pkg of 1 × 10 mg (700019P-10mg)
pkg of 1 × 100 mg (700019P-100mg)
pkg of 1 × 5 mg (700019P-5mg)
Produttore/marchio commerciale
Avanti Research™ - A Croda Brand
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
InChI
1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1
INBGSXNNRGWLJU-ZHHJOTBYSA-N
Descrizione generale
25-hydroxy-cholesterol is a side chain substituted oxysterol. Avanti′s unique sterol reverses cataracts in mice. Gestwicki′s team ...... settled on compound 29, a steroid found naturally in the bloodstream but not in the lens, which has no blood supply. Mice with age-related and hereditary cataracts received drops in the right eye, whereas the left eye went untreated. After just a few weeks, the treated eye was visibly clearer, says Gestwicki, who conducted the work while at the University of Michigan. Cataract severity is measured on a scale of zero to four, with four being the worst case. On average, mice in the study had about a one-grade improvement in cataract severity after 4 weeks of treatment. Science DOI: 10.1126/science.aad7400 It has been recently shown that activation of a macrophage toll-like receptor (TLR) by microbial antigens induces synthesis of 25-hydroxycholesterol, and that this oxysterol potently suppresses IgA production.
Applicazioni
- Inhibition Mechanism of SARS-CoV-2 Infection by a Cholesterol Derivative, Nat-20(S)-yne: This study explores how a cholesterol derivative, related to 25-hydroxycholesterol, inhibits SARS-CoV-2 infection, highlighting its potential in therapeutic applications for viral infections (Murae et al., 2024).
- 25-hydroxycholesterol promotes proliferation and metastasis of lung adenocarcinoma cells by regulating ERβ/TNFRSF17 axis: Demonstrates the role of 25-hydroxycholesterol in cancer biology, particularly in enhancing tumor growth and metastasis, providing insights for targeted cancer therapies (He et al., 2024).
- 25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages: Investigates how 25-hydroxycholesterol influences immune cells, particularly in the context of immune suppression and potential anti-inflammatory therapies (Xiao et al., 2024).
Confezionamento
5 mL Amber Glass Screw Cap Vial (700019P-100mg)
5 mL Amber Glass Screw Cap Vial (700019P-10mg)
5 mL Amber Glass Screw Cap Vial (700019P-5mg)
Note legali
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Comunemente ordinati con questo prodotto
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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I clienti hanno visto anche
Jason G Cyster et al.
Nature reviews. Immunology, 14(11), 731-743 (2014-10-18)
Cholesterol and components of the cholesterol biosynthetic pathway have fundamental roles in all mammalian cells. Hydroxylated forms of cholesterol are now emerging as important regulators of immune function. This involves effects on the cholesterol biosynthetic pathway and cell membrane properties
Leyuan Xu et al.
Lipids, 45(9), 821-832 (2010-08-12)
Dysregulation of lipid metabolism is frequently associated with inflammatory conditions. The mechanism of this association is still not clearly defined. Recently, we identified a nuclear oxysterol, 25-hydroxycholesterol-3-sulfate (25HC3S), as an important regulatory molecule involved in lipid metabolism in hepatocytes. The
Leah N Makley et al.
Science (New York, N.Y.), 350(6261), 674-677 (2015-11-07)
Cataracts reduce vision in 50% of individuals over 70 years of age and are a common form of blindness worldwide. Cataracts are caused when damage to the major lens crystallin proteins causes their misfolding and aggregation into insoluble amyloids. Using
Andrea Reboldi et al.
Science (New York, N.Y.), 345(6197), 679-684 (2014-08-12)
Type I interferon (IFN) protects against viruses, yet it also has a poorly understood suppressive influence on inflammation. Here, we report that activated mouse macrophages lacking the IFN-stimulated gene cholesterol 25-hydroxylase (Ch25h) and that are unable to produce the oxysterol
Samantha A Hutchinson et al.
Nutrients, 11(11) (2019-11-07)
Interventions that alter cholesterol have differential impacts on hormone receptor positive- and negative-breast cancer risk and prognosis. This implies differential regulation or response to cholesterol within different breast cancer subtypes. We evaluated differences in side-chain hydroxycholesterol and liver X nuclear
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