ALD00613

PSI²

• Sinonimo/i: Ψ², 2-(Perfluorophenoxy)-1,3,2-dithiaphospholane 2-sulfide, Achiral phosphorus-sulfur Incorporation reagent
• Formula empirica (notazione di Hill): C₈H₄F₅OPS₃
• Peso molecolare: 338.28
• Codice UNSPSC: 12352005
• NACRES: NA.22

Proprietà

• Stato: powder
• Livello qualitativo: 100
• Punto di fusione: 94-97 °C

Descrizione

Applicazioni

PSI² is a stable and sustainably prepared P(V) reagent developed by the Baran Lab for the synthesis of phosphorodithioate oligonucleotides. The phosphorodithioate linkages afforded by PSI² are effectively cleaved by RNAse-H while remaining stable to nucleases, and can be formed rapidly in high yield. The synthetic methodology accessed by PSI² and other PSI reagents (see ALD00602 and ALD00604) allows at will installation of a greater diversity of linkages to DNA and other nucleotides with comparable performance to existing state-of-the-art P(III) based reagents. The resulting compounds have applications in gene-based therapeutics such as antisense oligonucleotides (ASOs).

Learn more about PI and PSI reagents

Altre note

Unlocking P(V): Reagents for chiral phosphorothioate synthesis

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable