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Key Documents

933899

Sigma-Aldrich

N-(2-Hydroxy) propyl-3-trimethylammonium chitosan chloride

degree of quaternization 50%

Sinonimo/i:

Chioisan, HTCC, Quaternized Chitosan, Solube chitosan, TMC, Trimethyl chitoan

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About This Item

Formula condensata:
(C12H25N2O5Cl)n(C8H13NO5)m
Codice UNSPSC:
12352201
NACRES:
NA.21

Descrizione

NMR: Conforms to structure

Livello qualitativo

Forma fisica

(solid, chunks or fiber)

Colore

white to off-white

Temperatura di conservazione

2-8°C

Descrizione generale

Chitosan offers remarkable biological properties; it has been widely used in drug delivery and tissue engineering applications. Chitosan has good mucoadhesive properties due to its positive charge, which increases the adhesion to mucosa and facilitates drug penetration. Also, chitosan possesses hemostatic properties, which makes it a good candidate for wound dressing applications.

The quaternization of the primary amine increases the water solubility of chitosan and keeps chitosan soluble over a wide pH range. Cationically modified chitosan such as N-(2-Hydroxy)propyl-3-trimethyl ammonium chitosan chloride (HTCC) also imparts excellent antibacterial activity and immuno-enhancing characteristics. HTCC also used in gene delivery applications

Applicazioni

Small molecule and nucleic acid delivery
Tissue engineering
Antibacterial coatings

Caratteristiche e vantaggi

Water soluble
Cationically modified
Naturally derived and biocompatible

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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Bo Xiao et al.
Colloids and surfaces. B, Biointerfaces, 91, 168-174 (2011-11-23)
A series of N-(2-hydroxy)propyl-3-trimethyl ammonium chitosan chloride (HTCC) samples with various degrees of quaternization ranging from 12.4 to 43.7% was synthesized. The structures and properties of HTCC were investigated by FT-IR, (1)H NMR, conductometric titration and XRD analysis. It was
Hamid Hamedi et al.
Carbohydrate polymers, 199, 445-460 (2018-08-26)
Advanced development of chitosan hydrogels has led to new drug delivery systems that can release their active ingredients in response to environmental stimuli. This review considers more recent investigation of chitosan hydrogel preparations and the application of these preparations for

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