930083

2-(Pyrimidin-5-yl)phenol

≥95%

• Sinonimo/i: Maiti-Bag-Dutta Auxiliary
• Formula empirica (notazione di Hill): C₁₀H₈N₂O
• Numero CAS: 18313-50-3
• Peso molecolare: 172.18
• Numero MDL: MFCD06802618
• Codice UNSPSC: 12352100
• NACRES: NA.21

Proprietà

• Livello qualitativo: 100
• Saggio: ≥95%
• Stato: powder
• Punto di fusione: 173 °C
• Temperatura di conservazione: −20°C

Descrizione

Applicazioni

2-(Pyrimidin-5-yl)phenol is a temporary directing group (TDG) to assist as a co-catalyst for metal catalyzed C-H functionalization. Often in C-H functionalization, an auxiliary compound is used to control site selectivity. These traditionally are covalently bonded to the compound of interest, and must subsequently be removed after functionalization, like a typical protecting group. To simplify the process of C-H functionalization, 2-Fluoro-6-(pyrimidin-5-yl)aniline is one of a series of temporary directing groups developed by Deb Maiti′s lab that promote site selectivity without the inclusion of additional synthetic steps.

2-(Pyrimidin-5-yl)phenol is an effective TDG for meta directed C-H functionalization of substitutes with a variety of electron withdrawing functional groups, with high selectivity.

Altre note

Arene diversification through distal C(sp2)−H functionalization
Palladium-Catalyzed meta-C–H Allylation of Arenes: A Unique Combination of a Pyrimidine-Based Template and Hexafluoroisopropanol

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable