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925144

Sigma-Aldrich

KB05yne

≥95%

Sinonimo/i:

4-(N-(4-Bromophenyl)acrylamido)-N-(hex-5-yn-1-yl)benzamide, Functionalized scout fragment

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About This Item

Formula empirica (notazione di Hill):
C22H21BrN2O2
Peso molecolare:
425.32
Codice UNSPSC:
12352101
NACRES:
NA.22

Livello qualitativo

100

Saggio

≥95%

Stato

powder or solid

Impiego in reazioni chimiche

reagent type: chemical modification reagent
reaction type: click chemistry

Temperatura di conservazione

2-8°C

Categorie correlate

Applicazioni

KB05yne is a cysteine-reactive small-molecule fragment for chemoproteomic and ligandability studies for both traditionally druggable proteins as well as "undruggable," or difficult-to-target, proteins. This fragment electrophile is the functionalized version of KB02 (912131)

Related useful products may include: Cysteine-reactive fragments: KB02 (912131), KB03 (912654), KB05 (911798), sulfoxide (925136), CoLDR probe (923818) Functionalized scout fragments: KB02-COOH (925047), KB02yne (925225) Electrophilic degraders featuring scout fragments: KB02-SLF (914738), KB03-SLF (914975), KB05-SLF (913715), Biotin-SLF (914223) Cysteine-reactive probes for chemoproteomics: IA alkyne (924237), IA 5-TAMRA (925020), desthiobiotin iodoacetamide (923826), or biotin iodoacetamide (B2059)Related useful products may include: Cysteine-reactive fragments: KB02 (912131), KB03 (912654), KB05 (911798), sulfoxide (925136), CoLDR probe (923818) Functionalized scout fragments: KB02-COOH (925047), KB02yne (925225) Electrophilic degraders featuring scout fragments: KB02-SLF (914738), KB03-SLF (914975), KB05-SLF (913715), Biotin-SLF (914223) Cysteine-reactive probes for chemoproteomics: IA alkyne (924237), IA 5-TAMRA (925020), desthiobiotin iodoacetamide (923826), or biotin iodoacetamide (B2059)

Technology spotlight: Proteomic Ligandability Assessment

Altre note

Functionalized Scout Fragments for Site-Specific Covalent Ligand Discovery and Optimization

Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16

Prodotti correlati

N° Catalogo
Descrizione
Determinazione del prezzo

B2059

Biotin Polyethyleneoxide Iodoacetamide

699357

4-(Chloroacetyl)morpholine, 97%

911798

N-(4-Bromophenyl)-N-phenylacrylamide, ≥95%

912131

2-Chloro-1-(6-methoxy-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one, ≥95%

912654

N-(3,5-Bis(trifluoromethyl)phenyl)-2-chloroacetamide, ≥95%

914975

KB03-SLF, ≥95%

913715

KB05-SLF

914738

KB02-SLF, ≥95%

914223

Biotin-SLF

923818

N-(But-3-yn-1-yl)-2-(((2-oxo-2H-chromen-7-yl)oxy)methyl)acrylamide

925047

KB02-COOH

925225

KB02yne

925136

4,6-Dimethyl-2-(methylsulfinyl)-3-nitropyridine

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Lot/Batch Number

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Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16
Xiaoyu Zhang, et al
Nature Chemical Biology, 15(7), 737-746 (2019)

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