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Key Documents

Altri documenti

902551

Sigma-Aldrich

BocNH-PEG4-acid

Sinonimo/i:

2,2-Dimethyl-4-oxo-3,8,11,14,17-pentaoxa-5-azanonadecan-19-oic acid, Boc-NH-PEG4-CH2COOH

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About This Item

Formula empirica (notazione di Hill):
C15H29NO8
Numero CAS:
876345-13-0
Peso molecolare:
351.39
Codice UNSPSC:
12352106
NACRES:
NA.22

Forma fisica

liquid

Impiego in reazioni chimiche

reaction type: Pegylations
reagent type: cross-linking reagent

Indice di rifrazione

n/D 1.4641

Densità

1.1395 g/mL

Gruppo funzionale

Boc
amine
carboxylic acid

Temperatura di conservazione

−20°C

Stringa SMILE

OC(COCCOCCOCCOCCNC(OC(C)(C)C)=O)=O

Applicazioni

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. BocNH-PEG4-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Altre note

A Hexylchloride-Based Catch-and-Release System for Chemical Proteomic Applications

A Biocompatible Condensation Reaction for the Labeling of Terminal Cysteine Residues on Proteins

Note legali

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Prodotti correlati

N° Catalogo
Descrizione
Determinazione del prezzo

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Pomalidomide-PEG4-NH2 hydrochloride, ≥95%

901824

Pomalidomide-PEG4-CO2H

901848

(S,R,S)-AHPC-PEG4-NH2 hydrochloride, ≥95%

902683

BocNH-PEG5-acid

902675

BocNH-PEG6-acid

905208

Pomalidomide-C6-PEG3-butyl amine hydrochloride, ≥98%

907677

(S,R,S)-AHPC-PEG6-butyl chloride

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Erin A Losey et al.
Bioconjugate chemistry, 20(2), 376-383 (2009-01-16)
Cellular membranes play key roles in the regulation of a range of important biological processes. However, the characterization of membrane involvement in these events is difficult to achieve due to the complexity of the membrane bilayer and the challenges associated
Pratistha Ranjitkar et al.
Chemistry & biology, 17(2), 195-206 (2010-03-02)
A number of small-molecule inhibitors have been developed that target the catalytic domains of protein kinases that are not in an active conformation. An inactive form that has been observed in several kinases is the DFG-out conformation. This conformation is
BisPNA targeting to DNA: Effect of neutral loop on DNA duplex strand invasion by aepPNA-N7GlaepPNA-C substituted peptide nucleic acids
Shirude P S, et sl.
European Journal of Organic Chemistry, 2005, 5207-5215 (2005)
A biocompatible condensation reaction for the labeling of terminal cysteine residues on proteins.
Hongjun Ren et al.
Angewandte Chemie (International ed. in English), 48(51), 9658-9662 (2009-11-20)
Zinc(II) cyclen-peptide conjugates interacting with the weak effector binding state of RaS.
Rosnizeck I C, et al.
Inorgorganica Chimica Acta, 365 (1), 38-48 (2011)
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