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764736

Sigma-Aldrich

Poly(ethylene glycol) methyl ether-block-poly(D,L lactide)-block-decane

PEG average Mn 2,000, PDLLA average Mn 2,000

Sinonimo/i:

PEG-PDLLA-decane, PEG-b-PLA-b-decane, PEG-PLA

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About This Item

Codice UNSPSC:
12162002
NACRES:
NA.23

Forma fisica

pellets

PM

PDLLA average Mn 2,000
PEG average Mn 2,000
average Mn 4,000 (total)

Tempo di degradazione

2-5 weeks

Temp. transizione

Tm 29-33 °C

Ind. polidispersione

<1.1 (typical PEG)
<1.2
<1.3 (overall)

Temperatura di conservazione

2-8°C

Categorie correlate

Descrizione generale

Block copolymer micelles are widely used in drug delivery applications. PEG-PDLLA is a biodegradable polymeric micelle which is used as a carrier for hydrophobic drugs like Paclitaxel. The hydrophilic PEG and hydrophobic PDLLA form the micelle core wherein the hydrophobic drug is loaded. The incorporation of the 10-alkyl end cap (decane) increases the hydrophobicity of the micelle core and increases its solubilizing capability for hydrophobic drugs.†

Applicazioni

Used as a carrier for the controlled and targeted release of anticancer hydrophobic drugs.

Caratteristiche e vantaggi

  • Good biocompatibility, low immunogenicity and good degradability.
  • Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

>230.0 °F

Punto d’infiammabilità (°C)

> 110 °C

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Certificati d'analisi (COA)

Lot/Batch Number
MKBZ8548V
MKBX7526V
MKBP5197V

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Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide) PEG average Mn 2,000, PLGA average Mn 11,500

Sigma-Aldrich

764760

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)

Arunvel Kailasan et al.
Acta biomaterialia, 6(3), 1131-1139 (2009-09-01)
This work describes the synthesis and characterization of novel thermoresponsive highly branched polyamidoamine-polyethylene glycol-poly(D,L-lactide) (PAMAM-PEG-PDLLA) core-shell nanoparticles. A series of dendritic PEG-PDLLA nanoparticles were synthesized through conjugation of PEG of various chain lengths (1500, 6000 and 12,000 g mol(-1)) to
Hongtao Chen et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(18), 6596-6601 (2008-05-01)
It is generally assumed that polymeric micelles, upon administration into the blood stream, carry drug molecules until they are taken up into cells followed by intracellular release. The current work revisits this conventional wisdom. The study using dual-labeled micelles containing

Articoli

Solubility enhancement of hydrophobic drugs via drug-loaded micelles using biodegradable PEG- polyester diblock copolymers

One of the common difficulties with intravenous drug delivery is low solubility of the drug. The requirement for large quantities of saline to dissolve such materials limits their clinical use, and one solution for this problem that has recently generated interest is the formation of drug-loaded micelles.

Fabrication of Drug-loaded Microparticles Using Hydrogel Technology and Recent Innovation in Automation

Microparticle drug delivery systems have been extensively researched and applied to a wide variety of pharmaceutical and medical applications due to a number of advantages including injectability, local applicability to target tissues and sites, and controlled drug delivery over a given time period.

Electrospun Nanofibers for Drug Delivery Systems

Local delivery of bioactive molecules using an implantable device can decrease the amount of drug dose required as well as non-target site toxicities compared to oral or systemic drug administration.

Biodegradable Polyester-based Nanoparticle Formation by Miniemulsion Technique

Aliphatic polyesters such as polylactide, poly(lactide-co-glycolide) and polycaprolactone, as well as their copolymers, represent a diverse family of synthetic biodegradable polymers that have been widely explored for medical uses and are commercially available.

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