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Key Documents

735094

Sigma-Aldrich

Bis(2-methacryloyl)oxyethyl disulfide

contains ≤6000 ppm hydroquinone as stabilizer

Sinonimo/i:

DSDMA, Disulfide-based dimethacrylate

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About This Item

Formula empirica (notazione di Hill):
C12H18O4S2
Numero CAS:
Peso molecolare:
290.40
Numero MDL:
Codice UNSPSC:
12162002
ID PubChem:
NACRES:
NA.23

Forma fisica

liquid

Livello qualitativo

contiene

≤6000 ppm hydroquinone as stabilizer

Indice di rifrazione

n20/D 1.517

Densità

1.141 g/mL at 25 °C

Temperatura di conservazione

2-8°C

Stringa SMILE

CC(=C)C(=O)OCCSSCCOC(=O)C(C)=C

InChI

1S/C12H18O4S2/c1-9(2)11(13)15-5-7-17-18-8-6-16-12(14)10(3)4/h1,3,5-8H2,2,4H3
CGDNFXSLPGLMHK-UHFFFAOYSA-N

Descrizione generale

Bis(2-methacryloyl)oxyethyl disulfide (DSDMA) belongs to the class of monomers known as disulfide-based dimethacrylates. It is widely employed as a crosslinker in the synthesis of various polymers with specific properties such as redox sensitivity and self-healing properties. DSDMA contains a disulfide bond, which can be cleaved under specific conditions, making it useful for drug delivery systems. It also undergoes thiol-disulfide exchange reactions, allowing it to react with thiols in polymers and form covalent crosslinks. This property enables the formation of networks and gels in polymer systems. Additionally, DSDMA is employed in the development of biomedical materials, such as tissue engineering scaffolds. Its ability to form stable crosslinks in biological environments makes it suitable for these applications.

Applicazioni

Bis(2-methacryloyl)oxyethyl disulfide (DSDMA) can be used in the following applications:
  • Used as a crosslinker in the synthesis of reduction-responsive molecularly imprinted polymer (MIPs) nanogels for drug delivery applications. This reduction-responsive property allows for control over drug delivery and modulation of the release properties of the MIPs.
  • Used as a crosslinker in the synthesis of self-healing polymer nanocomposites via dynamic disulfide exchange reaction and crosslinking properties. These self-healing polymer nanocomposites can be used in coatings, electronics, and packaging applications.
  • Used as a redox-responsive cross-linker in the synthesis of zwitterionic hydrogels for effective drug delivery. DSDMA provides structural stability, redox-responsiveness, and self-healing properties, which are essential for effective drug delivery.

Pittogrammi

Environment

Indicazioni di pericolo

Consigli di prudenza

Classi di pericolo

Aquatic Chronic 2

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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Wenwen Li; Krzysztof Matyjaszewski; Krystyna Albrecht; Martin Moller
Macromolecules, 42, 8228-8228 (2009)
Kunihiko Kobayashi et al.
ACS applied materials & interfaces, 11(1), 151-159 (2018-12-12)
Soft-robotic devices such as polymeric microgrippers offer the possibility for pick and place of fragile biological cargo in hard-to-reach conduits with potential applications in drug delivery, minimally invasive surgery, and biomedical engineering. Previously, millimeter-sized self-folding thermomagnetically responsive soft grippers have
David S Spencer et al.
Journal of polymer science. Part A, Polymer chemistry, 56(14), 1536-1544 (2019-03-25)
Crosslinked cationic nanoscale networks with hydrophobic cores are an environmentally robust alternative to self-assembled polymeric drug delivery carriers with respect to therapeutic encapsulation and stability to dilution. However, the ability to tune the degree of PEG incorporated into nanogels during

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