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Key Documents

535311

Sigma-Aldrich

Poly(N-isopropylacrylamide)

Mn ~40,000

Sinonimo/i:

NIPAM polymer, PNIPAM, Polyacrylamide, polyNIPAM

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About This Item

Formula condensata:
CH3(C6H11NO)nCH3
Numero CAS:
Numero MDL:
Codice UNSPSC:
12162002
ID PubChem:
NACRES:
NA.23

PM

Mn 20,000-60,000
Mn ~40,000

Livello qualitativo

Punto di fusione

96 °C

Stringa SMILE

CC(C)NC(=O)C=C

InChI

1S/C6H11NO/c1-3-5-7-6(8)4-2/h4H,2-3,5H2,1H3,(H,7,8)
WDFKEEALECCKTJ-UHFFFAOYSA-N

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Applicazioni

Thermosensitive polymer, can be used to form a hydrogel. Aqueous polymer solution undergoes a phase transition from a soluble to an insoluble state when the temperature is raised to ca. 32 °C.

Stato fisico

Thermosensitive polymer, hydrogel

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)


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Manuel Pernia Leal et al.
ACS nano, 6(12), 10535-10545 (2012-11-03)
We report a procedure to grow thermo-responsive polymer shells at the surface of magnetic nanocarriers made of multiple iron oxide superparamagnetic nanoparticles embedded in poly(maleic anhydride-alt-1-ocatadecene) polymer nanobeads. Depending on the comonomers and on their relative composition, tunable phase transition
Albert J de Graaf et al.
Journal of controlled release : official journal of the Controlled Release Society, 162(3), 582-590 (2012-09-14)
In this paper it is shown that when a thermosensitive hydrogel based on poly(N-isopropylacrylamide)-poly(ethylene glycol)-poly(N-isopropylacrylamide) (pNIPAm-PEG-pNIPAm) was transferred into water, flower-like micelles were continuously released as long as the medium was regularly refreshed. On the other hand, if the medium
Guiying Li et al.
International journal of biological macromolecules, 50(4), 899-904 (2012-06-09)
Thermo-sensitive poly(N-isopropyl acrylamide-co-vinyl pyrrolidone)/chitosan [P(NIPAM-co-NVP)/CS] semi-IPN hydrogels with improved loading capacity and sustained release for anionic drugs NAP were prepared by free-radical polymerization. The LCST of hydrogels was adjusted to the vicinity of body temperature by introducing hydrophilic NVP. The
Jinseok Byun et al.
Chemical communications (Cambridge, England), 48(74), 9278-9280 (2012-08-09)
We report a novel approach for the fabrication of a photo-responsive surface with fast and reversibly switchable wettability between hydrophobicity and hydrophilicity induced by a photothermal effect.
Pengju Pan et al.
Langmuir : the ACS journal of surfaces and colloids, 28(40), 14347-14356 (2012-09-28)
Linear and miktoarm star-shaped diblock copolymers consisting of single-stranded DNA and poly(N-isopropylacrylamide) (PNIPAAm) with various compositions were synthesized via atom transfer radical polymerization and click chemistry. The temperature-responsive phase transition behavior, micellization, was systematically examined using UV-vis spectrometry, high-sensitivity differential

Articoli

Universal Platform for Surface Modification Employing Grafted Polymer Layers

Poly(N-isopropylacrylamide), or PNIPAM, is a stimuli-responsive polymer that responds to changes in pH and temperature and has a LCST around 32 C.

Tissue engineering has become a key therapeutic tool in the treatment of damaged or diseased organs and tissues, such as blood vessels and urinary bladders.

By altering the physicochemical properties, smart or intelligent drug delivery systems can be designed to deliver therapeutic molecules on-demand. Learn more about the application of stimuli-responsive materials in drug delivery.

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