41661

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone

absolute, over molecular sieve (H₂O ≤0.05%), ≥99.0% (GC)

• Sinonimo/i: 1,3-Dimethyl-2-oxohexahydropyrimidine, N,N′-Dimethylpropylene urea, DMPU
• Formula empirica (notazione di Hill): C₆H₁₂N₂O
• Numero CAS: 7226-23-5
• Peso molecolare: 128.17
• Beilstein: 110562
• Numero CE: 230-625-6
• Numero MDL: MFCD00006550
• Codice UNSPSC: 12352115
• ID PubChem: 57650056
• NACRES: NA.22

Proprietà

• Grado: absolute
• Livello qualitativo: 200
• Saggio: ≥99.0% (GC)
• Forma fisica: liquid
• Qualità: over molecular sieve (H₂O ≤0.05%)
• Indice di rifrazione: n20/D 1.488 (lit.); n20/D 1.489
• P. eboll.: 146 °C/44 mmHg (lit.)
• Densità: 1.06 g/mL at 25 °C (lit.)
• Stringa SMILE: CN1CCCN(C)C1=O
• InChI: 1S/C6H12N2O/c1-7-4-3-5-8(2)6(7)9/h3-5H2,1-2H3; GUVUOGQBMYCBQP-UHFFFAOYSA-N

Descrizione

Applicazioni

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone (DMPU) can be used as a:

• Solvent in the synthesis of 1-aryl-3,4,5-substituted pyrazoles by cyclocondensation of 1,3-diketones with arylhydrazine hydrochlorides.
• Chelating solvent in the trifluoromethylation of activated and non-activated halogenated double bonds.
• Ligand in ortho-alkylation of secondary benzamide catalyzed by cobalt.

Altre note

Aprotic, dipolar solvent, which is an excellent replacement of the carcinogenic HMPA as cosolvent for highly reactive nucleophiles and bases. High Z-selectivity in enolate formation; DMPU was shown to be non-mutagenic and safe.

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS05,GHS07
• Avvertenze: Danger
• Indicazioni di pericolo: H302,H318,H361f
• Consigli di prudenza: P202 - P264 - P280 - P301 + P312 - P305 + P351 + P338 - P308 + P313
• Classi di pericolo: Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 2
• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): 249.8 °F - closed cup
• Punto d’infiammabilità (°C): 121 °C - closed cup
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter