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136123

Sigma-Aldrich

trans-Chalcone

97%

Sinonimo/i:

Benzylideneacetophenone

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About This Item

Formula condensata:
C6H5CH=CHCOC6H5
Numero CAS:
614-47-1
Peso molecolare:
208.26
Numero CE:
210-383-8
Numero MDL:
MFCD00003082
Codice UNSPSC:
12352100
ID PubChem:
24848257
NACRES:
NA.22

Saggio

97%

Stato

solid

P. ebollizione

208 °C/25 mmHg (lit.)

Punto di fusione

55-57 °C (lit.)

Gruppo funzionale

ketone
phenyl

Stringa SMILE

[H]\C(=C(\[H])C(=O)c1ccccc1)c2ccccc2

InChI

1S/C15H12O/c16-15(14-9-5-2-6-10-14)12-11-13-7-3-1-4-8-13/h1-12H/b12-11+
DQFBYFPFKXHELB-VAWYXSNFSA-N

Informazioni sul gene

human ... IL1B(3553)
rat ... Ar(24208)

Categorie correlate

Descrizione generale

trans-Chalcone is an open chain flavonoid that may prevent lung and forestomach cancer.

Applicazioni

trans-Chalcone was used in the synthesis of cis and trans diphenyl cyclopropane. It was also used in screening of surface adsorbed species of isobutybenzene and 4-isobutylacetophenone on bulk fosfotungstic Wells-Dawson acid (H6P2W18O62.xH2O).

Azioni biochim/fisiol

trans-Chalcone exhibits antifungal activity against Trichophyton rubrum. It is inhibitor of fatty acid synthase and α-amylase. It induces programmed cell death due to reduced mitochondrial transmembrane potential in Arabidopsis thaliana roots.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302,H319,H335

Classi di pericolo

Acute Tox. 4 Oral - Eye Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
STBK6687
STBJ7806
STBJ5460
STBH4759
STBH3142

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4′-hydroxychalcone AldrichCPR

Sigma-Aldrich

CDS003892

4′-hydroxychalcone

4′-Methoxyacetophenone 99%

Sigma-Aldrich

117374

4′-Methoxyacetophenone

Acetophenone analytical standard

Supelco

42163

Acetophenone

Sylvie Ducki et al.
Bioorganic & medicinal chemistry, 17(22), 7698-7710 (2009-10-20)
The alpha-methyl chalcone SD400 is a potent inhibitor of tubulin assembly and possesses potent anticancer activity. Various chalcone analogues were synthesized and evaluated for their cell growth inhibitory properties against the K562 human chronic myelogenous leukemia cell line (SD400, IC(50)
Wattenberg L.W., et al.
Cancer Letters, 15, 165-165 (1994)
Daniela Batovska et al.
European journal of medicinal chemistry, 44(5), 2211-2218 (2008-07-01)
A large series of chalcones were synthesized and studied against Staphylococcus aureus and Escherichia coli. Chalcones were either unsubstituted in ring A or possessed 4'-chloro or 3',4',5'-trimethoxy groups. Their other ring B was variously substituted. It was found that the
Saeed Attar et al.
Bioorganic & medicinal chemistry, 19(6), 2055-2073 (2011-02-26)
A series of 30 organic chlacones and 33 ferrocenyl (Fc) chalcones were synthesized and characterized by melting point, elemental analysis, spectroscopy ((1)H NMR and FTIR) and, in two cases, by X-ray crystallography. The biological activity of each compound (10(-4)M in
Asha Budakoti et al.
European journal of medicinal chemistry, 44(3), 1317-1325 (2008-04-02)
In an effort to develop potent antiamoebic agents, we have synthesized chalcones (1-8), amino-5-substituted-(3-phenyl(2-pyrazolinyl))methane-1-thione derivatives (1a-8a) and 2-(5-substituted-3-phenyl-2-pyrazolinyl)-1,3-thiazolino[5,4-b]quinoxaline derivatives (1b-8b) and evaluated for their in vitro antiamoebic activity against HM1:IMSS strain of E. histolytica. All the compounds were characterized by
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