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  • Examination of growth inhibitory properties of synthetic chalcones for which antibacterial activity was predicted.

Examination of growth inhibitory properties of synthetic chalcones for which antibacterial activity was predicted.

European journal of medicinal chemistry (2008-07-01)
Daniela Batovska, Stoyan Parushev, Bistra Stamboliyska, Iva Tsvetkova, Mariana Ninova, Hristo Najdenski
ABSTRACT

A large series of chalcones were synthesized and studied against Staphylococcus aureus and Escherichia coli. Chalcones were either unsubstituted in ring A or possessed 4'-chloro or 3',4',5'-trimethoxy groups. Their other ring B was variously substituted. It was found that the anti-staphylococcal activity of chalcones was related to the energy difference between the two highest occupied molecular orbitals (HOMO and HOMO-1). Presence of hydroxyl group in ring B was not a determinant factor for the anti-staphylococcal activity, but the lipophilicity of ring A of the hydroxyl chalcones was of importance.

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Sigma-Aldrich
trans-Chalcone, 97%