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Key Documents

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109266

Sigma-Aldrich

Aminoguanidine bicarbonate

97%

Sinonimo/i:

Aminoguanidine hydrogencarbonate, Guanylhydrazine hydrogencarbonate

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About This Item

Formula condensata:
NH2NHC(=NH)NH2 · H2CO3
Numero CAS:
2582-30-1
Peso molecolare:
136.11
Beilstein:
3569869
Numero CE:
219-956-7
Numero MDL:
MFCD00012949
Codice UNSPSC:
12352100
ID PubChem:
24846902
NACRES:
NA.22

Saggio

97%

Punto di fusione

170-172 °C (dec.) (lit.)

Solubilità

H2O: soluble 2.7 g/L at 20 °C
H2O: soluble 3.3 g/L at 30 °C

Stringa SMILE

OC(O)=O.NNC(N)=N

InChI

1S/CH6N4.CH2O3/c2-1(3)5-4;2-1(3)4/h4H2,(H4,2,3,5);(H2,2,3,4)
OTXHZHQQWQTQMW-UHFFFAOYSA-N

Applicazioni

Aminoguanidine bicarbonate was used to study the effect of addition of polyamines to rat embryo cell cultures infected with adenovirus type 5.

Azioni biochim/fisiol

Aminoguanidine bicarbonate protects the cells infected with adenovirus from chromosomal damage. Aminoguanidine is a specific and highly effective inhibitor of diamine oxidase present in fetal calf serum.

Pittogrammi

Exclamation markEnvironment
GHS07,GHS09

Avvertenze

Warning

Indicazioni di pericolo

H317,H411

Consigli di prudenza

P273 - P280 - P302 + P352

Classi di pericolo

Aquatic Chronic 2 - Skin Sens. 1

Codice della classe di stoccaggio

13 - Non Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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5-Aminotetrazole monohydrate 97%

Sigma-Aldrich

A80602

5-Aminotetrazole monohydrate

8-Aminoguanine ≥95% (HPLC)

Sigma-Aldrich

SML1856

8-Aminoguanine

Guanabenz acetate United States Pharmacopeia (USP) Reference Standard

USP

1301404

Guanabenz acetate

Cinzia Antognelli et al.
Cells, 8(6) (2019-06-09)
Methylglyoxal (MG) is a potent inducer of advanced glycation end products (AGEs). MG, long considered a highly cytotoxic molecule with potential anticancer value, is now being re-evaluated to a protumorigenic agent in some malignancies. Anaplastic thyroid cancer (ATC) is an
A J Bellett et al.
Chromosoma, 84(4), 571-583 (1982-01-01)
Adenovirus uncouples DNA replication from polyamine biosynthesis and causes chromosome aberrations in rodent cells. Addition of polyamines protected infected cells from this chromosome damage. Spermine was the only individual polyamine which protected. The diamine oxidase inhibitor aminoguanidine also protected. Neither
Catiúcia R M O Matos et al.
Dalton transactions (Cambridge, England : 2003), 49(45), 16359-16367 (2020-05-28)
The Cu(ii) heptanuclear complex (Cu7atac) was synthesised using the hydrated amino acid ligand 2-(5-amino-1H-1,2,4-triazol-3-yl)acetic acid (Hatac·H2O). Single crystal X-ray diffraction analysis revealed a μ3-hydroxo bridged Cu(ii) heptanuclear complex, consisting of two triangular subunits and one Cu(ii) ion as a bridge
Sebastiano Intagliata et al.
Antioxidants (Basel, Switzerland), 10(1) (2020-12-31)
Resveratrol (RSV) is well known for its many beneficial activities, but its unfavorable physicochemical properties impair its effectiveness after systemic and topical administration; thus, several strategies have been investigated to improve RSV efficacy. With this aim, in this work, we
Paola Mirra et al.
Biochimica et biophysica acta, 1863(2), 440-449 (2016-11-20)
Methylglyoxal (MGO) is a reactive dicarbonyl produced as by-product of glycolysis, and its formation is heightened in hyperglycaemia. MGO plasma levels are two-fold to five-fold increased in diabetics and its accumulation promotes the progression of vascular complications. Impairment of endothelium-derived
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