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Merck

HTR2C

5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled

Sinonimi:
5-HT2C, 5-HTR2C, HTR1C
Specie:
Human HTR2C (3358), Mouse Htr2c (15560), Rat Htr2c (25187), naked mole-rat Htr2c (101726296), chicken HTR2C (428707), cow HTR2C (538909), Horse HTR2C (100057852), domestic cat HTR2C (101099620), dog HTR2C (450240)
ID UniProtKB:
P28335, B1AMW4, Q5VUF8, Q9NP28
ID gene:
  • Human(3358) Summary: Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
  • Mouse(15560) 5-hydroxytryptamine (serotonin) receptor 2C
  • Rat(25187) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
  • naked mole-rat(101726296) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
  • chicken(428707) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
  • cow(538909) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
  • Horse(100057852) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
  • domestic cat(101099620) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
  • dog(450240) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled

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Small Molecule - Agonist

N° Catalogo
Descrizione
Specie
D101
(±)-DOI hydrochloride, ≥98% (HPLC), solid,
Specie
human
A1362
Agomelatine, ≥98% (HPLC),
Specie
human
M110
α-Methylserotonin maleate salt, ≥98% (HPLC),
Specie
human
N7261
Nortriptyline hydrochloride, ≥98% (HPLC), powder,
Specie
human
M2525
Mianserin hydrochloride, ,
Specie
human

Small Molecule - Allosteric Modulator

N° Catalogo
Descrizione
Specie
D9190
DCEBIO, ≥98% (HPLC), solid,
Specie
human

Small Molecule - Antagonist

N° Catalogo
Descrizione
Specie
142360
4-Benzylpiperidine, 99%,
Specie
rat
300764
1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole, 98%,
Specie
rat
C-060
Cyclobenzaprine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®,
Specie
human
BP886
Cyclobenzaprine hydrochloride, British Pharmacopoeia (BP) Reference Standard,
Specie
human
C3200000
Cyclobenzaprine hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Specie
human

Antibodies

N° Catalogo
Descrizione
Reattività con
Applicazione
SAB4501477
Anti-5-HT-2C antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse, rat
Applicazione
ELISA
immunofluorescence
immunohistochemistry
SAB4501478
Anti-HTR2C antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse, rat
Applicazione
ELISA
western blot
SAB2500925
Anti-Serotonin Receptor 2C/HTR2C antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Reattività con
canine, human, mouse, rat
Applicazione
ELISA
western blot

Small Molecule - Blocker

N° Catalogo
Descrizione
Specie
M2525
Mianserin hydrochloride, ,
Specie
human
T6154
Trazodone hydrochloride, ≥99% (HPLC), powder,
Specie
human
T3146
Trimipramine maleate salt, ≥98% (TLC), powder,
Specie
human
Z101
Zimelidine dihydrochloride, solid,
Specie
human

Small Molecule - Inhibitor

N° Catalogo
Descrizione
Specie
T-030
Trazodone hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®,
Specie
human
BP591
Trazodone hydrochloride impurity standard, British Pharmacopoeia (BP) Reference Standard,
Specie
human
1673500
Trazodone hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Specie
human
BP590
Trazodone hydrochloride, British Pharmacopoeia (BP) Reference Standard,
Specie
human
N5536
Nefazodone hydrochloride, ≥98% (HPLC), solid,
Specie
human

Small Molecule - Ligand

N° Catalogo
Descrizione
Specie
M1514
Nω-Methyl-5-hydroxy­trypt­amine oxalate salt, ≥90% (HPLC),
Specie
human

Small Molecule - Metabolite

N° Catalogo
Descrizione
Specie
H8876
5-Hydroxyindole-3-acetic acid, ≥98% (HPLC), crystalline,
Specie
human

Small Molecule - Mixed Agonist/Antagonist

N° Catalogo
Descrizione
Specie
M8046
Mifepristone, ≥98%,
Specie
human, mouse, rat
H1512
Haloperidol, powder,
Specie
human, rat
C6305
Clozapine, ,
Specie
human, rat

Small Molecule - Precursor

N° Catalogo
Descrizione
Specie
H9772
5-Hydroxy-L-tryptophan, powder,
Specie
human

Proteins

N° Catalogo
Descrizione
Specie
HTS132M
ChemiSCREEN Human 5-HT2C Receptor Membrane Preparation, Human 5-HT2C GPCR membrane preparation for Radioligand binding Assays & GTPγS binding.,
Specie
human

esiRNA

N° Catalogo
Descrizione
Specie
EHU120291
MISSION® esiRNA, targeting human HTR2C,
Specie
human