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P0359

Sigma-Aldrich

Palmitoylethanolamide

≥98% (HPLC), powder, cannabinoid receptor agonist

Synonyme(s) :

N-(2-Hydroxyethyl)hexadecanamide, PEA, Palmidrol

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About This Item

Formule empirique (notation de Hill):
C18H37NO2
Numéro CAS:
544-31-0
Poids moléculaire :
299.49
Numéro CE :
208-867-9
Numéro MDL:
MFCD00020562
Code UNSPSC :
12352200
ID de substance PubChem :
24278619
Nomenclature NACRES :
NA.77

Nom du produit

Palmitoylethanolamide,

Forme

powder

Niveau de qualité

200

Température de stockage

−20°C

Chaîne SMILES 

CCCCCCCCCCCCCCCC(=O)NCCO

InChI

1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)19-16-17-20/h20H,2-17H2,1H3,(H,19,21)

Clé InChI

HXYVTAGFYLMHSO-UHFFFAOYSA-N

Informations sur le gène

human ... CNR1(1268) , CNR2(1269)
rat ... Faah(29347)

Application

Palmitoylethanolamide has been used as a reference standard in mass spectrometry (MS/MS).

Actions biochimiques/physiologiques

Palmitoylethanolamide (PEA) is a natural fatty acid amide of ethanolamine and palmitic acid. It is found in soybeans, egg yolk, and many other food sources. PEA is an endogenous cannabinoid receptor agonist. It is a peroxisome proliferator-activated receptor α (PPAR-α) ligand. PEA possesses anti-inflammatory, anti-allergic, neuroprotective, and analgesic activities. It belongs to the class of lipid mediators and the N-acylethanolamine family. PEA blocks the release of pro-inflammatory mediators from activated mast cells and prevents the recruitment of activated mast cells at the site of nerve injury.

Liaison

Structural analog of anandamide.

Pictogrammes

CorrosionEnvironment
GHS05,GHS09

Mention d'avertissement

Danger

Mentions de danger

H315,H318,H411

Classification des risques

Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2

Code de la classe de stockage

13 - Non Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
SLCH7858
SLCF6613
SLCF1209
SLCB5563
SLBV9913

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Millipore

495417-M

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GW6471 ≥98% (HPLC)

Sigma-Aldrich

G5045

GW6471

C18:1 anandamide Avanti Research™ - A Croda Brand 870432P, powder

Avanti

870432P

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GW7647 ≥98% (HPLC)

Sigma-Aldrich

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GW7647

Melania Melis et al.
The Laryngoscope, 129(9), E307-E312 (2019-01-25)
Taste sensitivity varies greatly among individuals influencing eating behavior and health, consequently the disorders of this sense can affect the quality of life. The ability to perceive the bitter of thiourea compounds, such as phenylthiocarbamide (PTC), has been largely reported
Didier M Lambert et al.
Current medicinal chemistry, 9(6), 663-674 (2002-04-12)
The discovery of anandamide as an endogenous ligand for the cannabinoid receptors has led to a resurgence of interest in the fatty acid amides. However, N-palmitoylethanolamine (PEA), a shorter and fully saturated analogue of anandamide, has been known since the
Xiao Shi et al.
PloS one, 11(3), e0152581-e0152581 (2016-04-01)
Methamphetamine (MA) and neurotransmitter precursors and metabolites such as tyramine, octopamine, and β-phenethylamine stimulate the G protein-coupled trace amine-associated receptor 1 (TAAR1). TAAR1 has been implicated in human conditions including obesity, schizophrenia, depression, fibromyalgia, migraine, and addiction. Additionally TAAR1 is
Tessa L Crume et al.
American journal of obstetrics and gynecology, 215(5), 609-609 (2016-10-30)
Consistent evidence of an influence of maternal dietary intake during pregnancy on infant body size and composition in human populations is lacking, despite robust evidence in animal models. We sought to evaluate the influence of maternal macronutrient intake and balance
Lili He et al.
Journal of chromatographic science, 54(8), 1428-1434 (2016-05-04)
This article aims to build up a simple, rapid and accurate capillary zone electrophoresis (CZE) method for the separation of biogenic amines (BAs). Here, 10 key BAs (phenethylamine, histamine, tryptamine, tyramine, 5-hydroxytryptamine, octopamine, dopamine, norepinephrine, epinephrine and carnosine) owning significant
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