T6700

TRAM-34

≥98% (HPLC), solid

• Synonym(e): 1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole
• Empirische Formel (Hill-System): C₂₂H₁₇ClN₂
• CAS-Nummer: 289905-88-0
• Molekulargewicht: 344.84
• MDL-Nummer: MFCD09842562
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329826852
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: solid
• Farbe: off-white
• Löslichkeit: DMSO: 2 mg/mL; H₂O: insoluble
• Lagertemp.: 2-8°C
• SMILES String: Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4cccn4
• InChI: 1S/C22H17ClN2/c23-21-15-8-7-14-20(21)22(25-17-9-16-24-25,18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-17H
• InChIKey: KBFUQFVFYYBHBT-UHFFFAOYSA-N

Beschreibung

Anwendung

TRAM-34 has been used to study its effect on the prevention of vascular restenosis after balloon angioplasty.

Biochem./physiol. Wirkung

TRAM-34 exhibits 100-fold selectivity (K_d = 20 nM) for IK_Ca1 channels over other K⁺ channels (Charybdotoxin, K_d = 5 nM, Clotrimazole, K_d = 70 nM; Nitrendipine K_d = 900 nM). Furthermore, TRAM-34 is known to suppress the activation of human T lymphocytes,.

TRAM-34 is a potent inhibitor of the intermediate-conductance Ca²⁺-activated K⁺ channel.

Leistungsmerkmale und Vorteile

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Angaben zur Herstellung

TRAM-34 is soluble in DMSO at 2 mg/ml. However, it is insoluble in water.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302,H413
• P-Sätze: P264 - P270 - P273 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral - Aquatic Chronic 4
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves