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SRP0371

PKG1alpha active human

Name: PKG1alpha active human
Brand: SIGMA

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE)

Synonym(e):

PRKG1, PRKGR1B, protein kinase, cGMP-dependent, type I

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About This Item

CAS-Nummer:

141588-27-4

UNSPSC-Code:

12352200

NACRES:

NA.32

Biologische Quelle

human

Rekombinant

expressed in baculovirus infected Sf9 cells

Assay

≥70% (SDS-PAGE)

Form

aqueous solution

Mol-Gew.

80 kDa

Verpackung

pkg of 10 μg

Lagerbedingungen

avoid repeated freeze/thaw cycles

Konzentration

0.45 mg/mL

Methode(n)

activity assay: suitable
inhibition assay: suitable

NCBI-Hinterlegungsnummer

NM_001098512

UniProt-Hinterlegungsnummer

Q13976

Versandbedingung

dry ice

Lagertemp.

−70°C

Angaben zum Gen

human ... PRKG1(5592)

Allgemeine Beschreibung

cGMP dependent Human PKG1alpha (GenBank Accession No. NM_001098512), full length with N-terminal His-tag, MW = 80 kDa, expressed in Baculovirus infected Sf9 cell expression system.

Anwendung

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Probing the interaction between the coiled coil leucine zipper of cGMP-dependent protein kinase Ialpha and the C terminus of the myosin binding subunit of the myosin light chain phosphatase.

Alok K Sharma et al.

The Journal of biological chemistry, 283(47), 32860-32869 (2008-09-11)

Nitric oxide and nitrovasodilators induce vascular smooth muscle cell relaxation in part by cGMP-dependent protein kinase I (PKG-Ialpha)-mediated activation of myosin phosphatase (MLCP). Mechanistically it has been proposed that protein-protein interactions between the N-terminal leucine zipper (LZ) domain of PKG-Ialpha

Expression, purification, and characterization of the cGMP-dependent protein kinases I beta and II using the baculovirus system.

D Pöhler et al.

FEBS letters, 374(3), 419-425 (1995-11-06)

Detailed studies of differences in distinct cGMP kinase isoforms are highly dependent on expression of large amounts of these enzyme isoforms that are not easily purified by conventional methods. Here cGMP-dependent protein kinases, the type I beta soluble form from

CHIP phosphorylation by protein kinase G enhances protein quality control and attenuates cardiac ischemic injury.

Mark J Ranek et al.

Nature communications, 11(1), 5237-5237 (2020-10-22)

Proteotoxicity from insufficient clearance of misfolded/damaged proteins underlies many diseases. Carboxyl terminus of Hsc70-interacting protein (CHIP) is an important regulator of proteostasis in many cells, having E3-ligase and chaperone functions and often directing damaged proteins towards proteasome recycling. While enhancing

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