G5918

GR 113808

≥98% (HPLC), solid

• Synonym(e): 1-[2-[(Methylsulfonyl)-amino]ethyl]-4-piperidinyl]methyl 1-methyl-1H-indole-3-carboxylate
• Empirische Formel (Hill-System): C₁₉H₂₇N₃O₄S
• CAS-Nummer: 144625-51-4
• Molekulargewicht: 393.50
• MDL-Nummer: MFCD00912901
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278311
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: solid
• Farbe: white to light pink
• Löslichkeit: DMSO: >20 mg/mL
• Ersteller: GlaxoSmithKline
• Lagertemp.: 2-8°C
• SMILES String: Cn1cc(C(=O)OCC2CCN(CCNS(C)(=O)=O)CC2)c3ccccc13
• InChI: 1S/C19H27N3O4S/c1-21-13-17(16-5-3-4-6-18(16)21)19(23)26-14-15-7-10-22(11-8-15)12-9-20-27(2,24)25/h3-6,13,15,20H,7-12,14H2,1-2H3
• InChIKey: MOZPSIXKYJUTKI-UHFFFAOYSA-N
• Angaben zum Gen: human ... HTR4(3360) ; rat ... Htr3a(79246) , Htr4(25324)

Beschreibung

Anwendung

GR 113808 has been used as a serotonin receptor 4 (5-HT4R) blocker to study its effects on the calcium (Ca²⁺) transients in rat ventricular cardiomyocytes. It has also been used as a 5-HT4R antagonist to study its effects on de novo enteric neurogenesis in post-embryonic zebrafish.

Biochem./physiol. Wirkung

GR 113808 is a 5-HT₄ serotonin receptor antagonist.

Leistungsmerkmale und Vorteile

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Rechtliche Hinweise

Sold for research purposes under agreement from Glaxo­Smith­Kline

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)