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L9668

Sigma-Aldrich

Lidoflazine

≥98% (HPLC), powder

Synonym(e):

4-[4,4-Bis(4-fluorophenyl)butyl]-N-(2,6-dimethylphenyl)-1-piperazineacetamide

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About This Item

Empirische Formel (Hill-System):
C30H35F2N3O
CAS-Nummer:
3416-26-0
Molekulargewicht:
491.62
EG-Nummer:
222-312-8
MDL-Nummer:
MFCD00057353
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329817673
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

powder

Farbe

white

Löslichkeit

DMSO: ≥10 mg/mL

Lagertemp.

2-8°C

SMILES String

Cc1cccc(C)c1NC(=O)CN2CCN(CCCC(c3ccc(F)cc3)c4ccc(F)cc4)CC2

InChI

1S/C30H35F2N3O/c1-22-5-3-6-23(2)30(22)33-29(36)21-35-19-17-34(18-20-35)16-4-7-28(24-8-12-26(31)13-9-24)25-10-14-27(32)15-11-25/h3,5-6,8-15,28H,4,7,16-21H2,1-2H3,(H,33,36)

InChIKey

ZBIAKUMOEKILTF-UHFFFAOYSA-N

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Biochem./physiol. Wirkung

Lidoflazine is an antianginal calcium channel blocker that carries a significant risk of QT interval prolongation and ventricular arrhythmia. It prolongs QT interval by blocking HERG channel. IC50 < 0.1 μM

Leistungsmerkmale und Vorteile

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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G J Grover et al.
The Journal of pharmacology and experimental therapeutics, 268(1), 90-96 (1994-01-01)
The goal of this study was to determine the cardioprotective profile for the nucleoside transport inhibitor 2-(aminocarboxyl)-N-(4-amino-2,6-dichlorophenyl)-4-[5,5-bis(4- fluorophenyl)pentyl]-1-piperazinylacetamide trihydrochloride-2,5 hydrate (R 75231) in isolated rat hearts and whether its protective effects are caused by adenosine A1 activation. R 75231 increased
Thomas P Zonneveld et al.
The Cochrane database of systematic reviews, 7, CD007858-CD007858 (2018-07-20)
Stroke is an important cause of death and disability worldwide. Since high blood pressure is an important risk factor for stroke and stroke recurrence, drugs that lower blood pressure might play an important role in secondary stroke prevention. To investigate
S G De Hert et al.
Acta anaesthesiologica Scandinavica, 38(5), 479-485 (1994-07-01)
A significant central-to-peripheral arterial pressure gradient may exist during and after cardiopulmonary bypass (CPB). The etiology and mechanisms of this phenomenon remain controversial. We studied the pressure gradient between aorta, brachial artery and radial artery in 68 patients, scheduled for
H J Rogove et al.
Critical care medicine, 23(1), 18-25 (1995-01-01)
To assess survival after cardiac arrest and to determine whether age is an independent determinant of late mortality or poor neurologic outcome. Analyses using results of Brain Resuscitation Clinical Trial I (1979 to 1984) and Brain Resuscitation Clinical Trial II
S G De Hert et al.
Journal of cardiothoracic and vascular anesthesia, 11(1), 42-48 (1997-02-01)
The present study evaluated the effects of the nucleoside transport inhibitor, lidoflazine, at a dose of 1 mg/kg, on left ventricular function. Patients were randomly assigned to receive either lidoflazine or saline in a double-blind manner. A university hospital. The
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