I2142

KN-62

≥95%, powder

• Synonym(e): (S)-5-Isoquinolinesulfonic acid 4-[2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester, 1-[N,O-bis(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine
• Empirische Formel (Hill-System): C₃₈H₃₅N₅O₆S₂
• CAS-Nummer: 127191-97-3
• Molekulargewicht: 721.84
• MDL-Nummer: MFCD00083180
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24895961
• NACRES: NA.77

Eigenschaften

• Biologische Quelle: synthetic (organic)
• Assay: ≥95%
• Form: powder
• Farbe: yellow
• mp (Schmelzpunkt): 130 °C
• Löslichkeit: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.93 mg/mL; methanol: 10 mg/mL; DMSO: 12 mg/mL; chloroform: 20 mg/mL
• Lagertemp.: −20°C
• SMILES String: O=S(OC1=CC=C(C[C@@H](C(N2CCN(C3=CC=CC=C3)CC2)=O)N(C)S(C4=CC=CC5=C4C=CN=C5)(=O)=O)C=C1)(C6=CC=CC7=C6C=CN=C7)=O
• InChI: 1S/C38H35N5O6S2/c1-41(50(45,46)36-11-5-7-29-26-39-19-17-33(29)36)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)49-51(47,48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20,26-27,35H,21-25H2,1H3/t35-/m0/s1
• InChIKey: RJVLFQBBRSMWHX-DHUJRADRSA-N
• Angaben zum Gen: human ... P2RX7(5027)

Beschreibung

Biochem./physiol. Wirkung

Selectively inhibits rat brain Ca²⁺/calmodulin-dependent protein kinase II.

Leistungsmerkmale und Vorteile

This compound is featured on the Ca/CaMKs and P2 Receptors: P2X Ion Channel Family pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)