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C1172

Sigma-Aldrich

ML-9

≥99% (TLC), powder

Synonym(e):

1-(5-Chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride

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About This Item

Lineare Formel:
C15H17N2O2SCl · HCl
CAS-Nummer:
105637-50-1
Molekulargewicht:
361.29
MDL-Nummer:
MFCD00065525
UNSPSC-Code:
12352202
PubChem Substanz-ID:
24278297
NACRES:
NA.77

Biologische Quelle

synthetic (organic)

Assay

≥99% (TLC)

Form

powder

Farbe

white

Löslichkeit

ethanol: 10 mg/mL

Lagertemp.

2-8°C

SMILES String

Cl.Clc1cccc2c(cccc12)S(=O)(=O)N3CCCNCC3

InChI

1S/C15H17ClN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H

InChIKey

ZNRYCIVTNLZOGI-UHFFFAOYSA-N

Angaben zum Gen

human ... SLC2A1(6513) , SLC2A4(6517)

Anwendung

ML-9 has been used in the inhibition of myosin light chain kinase (MLCK) and non-muscle myosin IIA (NMIIA) in human corneal epithelial cells and HeLa cells.

Biochem./physiol. Wirkung

ML-9 is myosin light chain kinase inhibitor. It inhibits insulin-induced translocation of glucose transporters GLUT4 and GLUT1 in a dose-dependent manner. ML-9 also inhibits agonist-induced Ca2+ entry into endothelial cells and catecholamine secretion in intact and permeabilized chromaffin cells. ML-9 promotes cell death in cancer cells by triggering accumulation of autophagic vacuoles. ML-9 impacts phosphorylation of myosin light chain kinase and alters trabecular meshwork shape and decreases intraocular pressure in rabbit eyes.

Leistungsmerkmale und Vorteile

This compound is featured on the Ca/CaMKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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The adrenal medulla (1992)
Letitia Weigand et al.
American journal of physiology. Lung cellular and molecular physiology, 290(2), L284-L290 (2005-09-13)
Endothelin-1 (ET-1), a potent vasoconstrictor, is believed to contribute to the pathogenesis of hypoxic pulmonary hypertension. Previously we demonstrated that contraction induced by ET-1 in intrapulmonary arteries (IPA) from chronically hypoxic (CH) rats occurred independently of changes in intracellular Ca2+
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Durkin CH, et al.
Developmental Cell, 41(3), 315-329 (2017)
G Inoue et al.
The Journal of biological chemistry, 268(7), 5272-5278 (1993-03-05)
Treatment of 3T3-L1 adipocytes with insulin resulted in activation of 2-deoxyglucose transport activity and translocation of glucose transporters (GLUT4 and GLUT1) from the cytoplasmic space to the plasma membrane. ML-9 (a myosin light chain kinase inhibitor) inhibited insulin stimulation of
Amy Peng et al.
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Synaptic vesicle exo- and endocytosis are usually driven by neuronal activity but can also occur spontaneously. The identity and differences between vesicles supporting evoked and spontaneous neurotransmission remain highly debated. Here we combined nanometer-resolution imaging with a transient motion analysis
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