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I2764

Sigma-Aldrich

ML-7

powder

Synonym(e):

1-(5-Iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride

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About This Item

Empirische Formel (Hill-System):
C15H17IN2O2S · HCl
CAS-Nummer:
110448-33-4
Molekulargewicht:
452.74
MDL-Nummer:
MFCD00065524
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24278490
NACRES:
NA.77

Assay

≥98% (TLC)

Qualitätsniveau

200

Form

powder

Farbe

white

Löslichkeit

ethanol: water (1:1): 10 mg/mL, clear, colorless to faintly yellow

Lagertemp.

−20°C

SMILES String

Cl.Ic1cccc2c(cccc12)S(=O)(=O)N3CCCNCC3

InChI

1S/C15H17IN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H

InChIKey

KDDALCDYHZIZMH-UHFFFAOYSA-N

Angaben zum Gen

human ... MYLK(4638) , MYLK2(85366)

Anwendung

ML-7 has been used as a myosin light chain kinase (MLCK) inhibitor in various experiments.

Biochem./physiol. Wirkung

Selective myosin light chain kinase inhibitor.

Leistungsmerkmale und Vorteile

This compound is featured on the Ca/CaMKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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Iwona Bil-Lula et al.
Frontiers in bioscience (Landmark edition), 23, 298-309 (2017-09-21)
Matrix metalloproteinase-2 (MMP-2) mediated degradation of myosin light chain 1 (MLC1) and troponin I (TnI) contributes to myocardial ischemia/reperfusion (I/R) injury. Modifications of MLC1 triggered by oxidative stress are mediated by myosin light chain kinase (MLCK), nitric oxide synthase (NOS)
Ziad Al Nabhani et al.
Inflammatory bowel diseases, 23(7), 1109-1119 (2017-05-19)
Crohn's disease (CD) pathogenesis is multifactorial involving genetic and environmental factors. Loss of function mutations in the nucleotide oligomerization domain 2 (NOD2) gene are the main genetic risk factor for CD. Like patients with CD, Nod2 mice are characterized by
M Makishima et al.
FEBS letters, 287(1-2), 175-177 (1991-08-05)
Inhibitors of myosin light chain kinase, 1-(5-chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride (ML-9) and 1-(5-iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride (ML-7), induced Nitroblue tetrazolium reducing activity, lysozyme activity and morphological maturation of human monoblastic U937, THP-1 and promyelocytic HL-60 cells, but not of erythroblastic K562 cells. However, three
Zasp/Cypher internal ZM-motif containing fragments are sufficient to co-localize with alpha-actinin?Analysis of patient mutations
Klaavuniemi T and Ylanne J
Experimental Cell Research, 312(8), 1299-1311 (2006)
Jing Du et al.
Cell systems, 9(2), 214-220 (2019-07-08)
Mechanical factors play critical roles in mammalian development. Here, we report that colony-growing mouse embryonic stem cells (mESCs) generate significant tension on the colony surface through the contraction of a three-dimensional supracellular actomyosin cortex (3D-SAC). Disruption of the 3D-SAC, whose
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