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A9561

Sigma-Aldrich

5-(N,N-Hexamethylene)amiloride

Synonym(e):

HMA

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About This Item

Empirische Formel (Hill-System):
C12H18ClN7O
CAS-Nummer:
1428-95-1
Molekulargewicht:
311.77
MDL-Nummer:
MFCD00069211
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24278246
NACRES:
NA.77

Form

powder

Qualitätsniveau

200

Lagertemp.

2-8°C

SMILES String

N\C(N)=N\C(=O)c1nc(Cl)c(nc1N)N2CCCCCC2

InChI

1S/C12H18ClN7O/c13-8-10(20-5-3-1-2-4-6-20)18-9(14)7(17-8)11(21)19-12(15)16/h1-6H2,(H2,14,18)(H4,15,16,19,21)

InChIKey

RQQJJXVETXFINY-UHFFFAOYSA-N

Angaben zum Gen

human ... SCNN1A(6337) , SCNN1B(6338) , SCNN1D(6339) , SCNN1G(6340) , SLC9A1(6548) , SLC9A5(6553)
mouse ... Scnn1a(20276) , Scnn1b(20277) , Scnn1d(140501) , Scnn1g(20278)
rat ... Scnn1a(25122) , Scnn1b(24767) , Scnn1g(24768) , Slc9a1(24782) , Slc9a3(24784)

Biochem./physiol. Wirkung

Inhibitor of Na+/H+ antiport.

Leistungsmerkmale und Vorteile

This compound is featured on the P2 Receptors: P2X Ion Channel Family page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Piktogramme

Skull and crossbones
GHS06

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Roland Montserret et al.
The Journal of biological chemistry, 285(41), 31446-31461 (2010-07-30)
The small membrane protein p7 of hepatitis C virus forms oligomers and exhibits ion channel activity essential for virus infectivity. These viroporin features render p7 an attractive target for antiviral drug development. In this study, p7 from strain HCV-J (genotype
Konstantin Pervushin et al.
PLoS pathogens, 5(7), e1000511-e1000511 (2009-07-14)
The envelope (E) protein from coronaviruses is a small polypeptide that contains at least one alpha-helical transmembrane domain. Absence, or inactivation, of E protein results in attenuated viruses, due to alterations in either virion morphology or tropism. Apart from its
B Masereel et al.
European journal of medicinal chemistry, 38(6), 547-554 (2003-07-02)
The Na(+)/H(+) exchanger (NHE) is involved in intracellular pH homeostasis of many mammalian cell types. To date seven NHE isoforms (NHE1-NHE7) have been identified. NHE1 is the most predominant isoform expressed in heart where it contributes to cardiomyocyte pH homeostasis.
A Premkumar et al.
FEBS letters, 557(1-3), 99-103 (2004-01-27)
A 63 residue peptide, p7, encoded by hepatitis C virus was synthesised and tested for ion channel activity in lipid bilayer membranes. Ion channels formed by p7 had a variable conductance: some channels had conductances as low as 14 pS.
A Premkumar et al.
The Journal of membrane biology, 204(1), 33-38 (2005-07-12)
A chemically synthesized peptide consisting of the C-terminus of the M protein of the Dengue virus type 1 strain Singapore S275/90 (DVM-C) produced ion channel activity in artificial lipid bilayers. The channels had a variable conductance and were more permeable
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