582231

Tetanustoxoid, Clostridium tetani

This tetanus toxoid is prepared by formaldehyde inactivation of tetanus toxin. It retains its antigenic character, but is essentially nontoxic as determined by an LD₅₀ in mice.

• Synonym(e): TTx
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 200
• Form: lyophilized
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze
• Versandbedingung: ambient
• Lagertemp.: 2-8°C

Beschreibung

Biochem./physiol. Wirkung

Tetanus Toxoid acts against Clostridium tetani, a gram-positive bacillus that produces a neurotoxin called tetanospasmin. Tetanospasmin prevents the release of an inhibitory neurotransmitter and causes unopposed muscle contractions and spasms. Tetanus toxoid vaccine stimulates the immune system to respond to the vaccine’s antigens. The immune system’s T-lymphocytes (TH2 and B cells) secrete immunoglobulin against the antigen in the vaccine. This immunoglobulin helps to protect against future infections.

Warnhinweis

Toxizität: Standard-Handhabung (A)

Physikalische Form

Lyophilisiert aus 100 mM Histidin, 100 mM NaCI, 5 % Trehalose, pH 7,0.

Rekonstituierung

In 50 µL sterilem, destilliertem H₂O rekonstituieren

Sonstige Hinweise

Wrenger, S., et al. 2000. J. Biol. Chem.275, 22180.
Habermann E. und Goretzki, K. 1985. In Monoclonal Antibodies Against Bacteria (Macario, A.J.L., und Conway de Macario, E. Hrsg.) Academic Press, New York, p.191.
Kozbor, D. und Roder, J.C. 1981. J. Immunol.127, 1275.
Bizzini, B., et al. 1970. Eur. J. Biochem.17, 100.
Largier, J.F. und Joubert, F.J. 1956. Biochem. Biophys. Acta20, 407.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable