928348

BrettPhos ChemBeads

• Synonym(e): 2-(Dicyclohexylphosphino)3,6-dimethoxy-2′,4′,6′-triisopropyl-1,1′-biphenyl
• Empirische Formel (Hill-System): C₃₅H₅₃O₂P
• CAS-Nummer: 1070663-78-3
• Molekulargewicht: 536.77
• MDL-Nummer: MFCD11973797
• UNSPSC-Code: 12352112
• NACRES: NA.82

Eigenschaften

• Form: solid
• Qualitätsniveau: 100
• Zusammensetzung: ~ 5 wt.% loading of catalyst
• Eignung der Reaktion: reagent type: catalyst; reaction type: Cross Couplings
• InChI: 1S/C35H53O2P/c1-23(2)26-21-29(24(3)4)33(30(22-26)25(5)6)34-31(36-7)19-20-32(37-8)35(34)38(27-15-11-9-12-16-27)28-17-13-10-14-18-28/h19-25,27-28H,9-18H2,1-8H3
• InChIKey: WDVGNXKCFBOKDF-UHFFFAOYSA-N

Beschreibung

Anwendung

BrettPhos is a dialkylbiaryl phosphine ligand developed by the Buchwald group. It promotes cross-coupling reactions more efficiently and exhibits improved reactivity compared to other catalytic systems.


It can be used in:

• palladium-catalyzed trifluoromethylation of aryl chlorides
• Buchwald-Hartwig amination
• synthesis of 4-aryl and alkyl substituted, N6-alkylated pyridazine-3,6-diamines via a Buchwald protocol

ChemBeads are chemical coated glass beads. ChemBeads offer improved flowability and chemical uniformity perfect for automated solid dispensing and high-throughput experimentation. The method of creating ChemBeads uses no other chemicals or surfactants allowing the user to accurately dispense sub-milligram amounts of chemical.

Learn more about ChemBeads products

For larger scale uses, product also available in powdered form (718742)

Sonstige Hinweise

High-Throughput Reaction Screening with Nanomoles of Solid Reagents Coated on Glass Beads

Versatile Methods to Dispense Sub-Milligram Quantities of Solids using Chemical Coated Beads for High-Throughput Experimentation

ChemBead Enabled High-Throughput Cross-Electrophile Coupling Reveals a New Complementary Ligand

Sicherheitshinweise

• Piktogramme: GHS08
• Signalwort: Danger
• H-Sätze: H350i
• P-Sätze: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Gefahreneinstufungen: Carc. 1B Inhalation
• Lagerklassenschlüssel: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• WGK: WGK 1