718742

2-(Dicyclohexylphosphino)-3,6-dimethoxy-2′,4′,6′-triisopropyl-1,1′-biphenyl

98%

• Synonym(e): BrettPhos
• Empirische Formel (Hill-System): C₃₅H₅₃O₂P
• CAS-Nummer: 1070663-78-3
• Molekulargewicht: 536.77
• MDL-Nummer: MFCD11973797
• UNSPSC-Code: 12352112
• PubChem Substanz-ID: 329763602
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 300
• Assay: 98%
• Form: solid
• Eignung der Reaktion: reaction type: Cross Couplings; reagent type: ligand; reaction type: Buchwald-Hartwig Cross Coupling Reaction; reagent type: ligand; reaction type: Fluorinations
• Grünere Alternativprodukt-Bewertung: old score: 8; new score: 1; Find out more about DOZN™ Scoring
• Grünere Alternativprodukt-Eigenschaften: Waste Prevention; Atom Economy; Design for Energy Efficiency; Learn more about the Principles of Green Chemistry.
• mp (Schmelzpunkt): 187-195 °C
• Funktionelle Gruppe: phosphine
• Grünere Alternativprodukt-Kategorie: , Re-engineered
• SMILES String: COc1c(P(C2CCCCC2)C3CCCCC3)c(c4c(C(C)C)cc(C(C)C)cc4C(C)C)c(OC)cc1
• InChI: 1S/C35H53O2P/c1-23(2)26-21-29(24(3)4)33(30(22-26)25(5)6)34-31(36-7)19-20-32(37-8)35(34)38(27-15-11-9-12-16-27)28-17-13-10-14-18-28/h19-25,27-28H,9-18H2,1-8H3
• InChIKey: WDVGNXKCFBOKDF-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles “Waste Prevention”, “Atom Economy” and “Design for Energy Efficiency”. Click here to view its DOZN scorecard.

Anwendung

Buchwald Phosphine Ligands for chemical Synthesis

BrettPhos is a dialkylbiaryl phosphine ligand developed by the Buchwald group. It promotes cross-coupling reactions more efficiently and exhibits improved reactivity compared to other catalytic systems.
It can be used in:

• palladium-catalyzed trifluoromethylation of aryl chlorides
• Buchwald-Hartwig amination
• synthesis of 4-aryl and alkyl substituted, N⁶-alkylated pyridazine-3,6-diamines via a Buchwald protocol

For small scale and high throughput uses, product is also available as ChemBeads (928348)

Leistungsmerkmale und Vorteile

• White crystalline solid
• Air- and moisture-stable
• Thermally stable
• Highly efficient
• Wide functional group tolerance
• Excellent selectivity and conversion

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: nwg
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable