384410

Chlortrimethylsilan -Lösung

1.0 M in THF

• Synonym(e): Trimethyl-chlorsilan -Lösung
• Lineare Formel: (CH₃)₃SiCl
• CAS-Nummer: 75-77-4
• Molekulargewicht: 108.64
• Beilstein: 1209232
• MDL-Nummer: MFCD00000502
• UNSPSC-Code: 12352302
• PubChem Substanz-ID: 24863995
• NACRES: NA.22

Eigenschaften

• Form: liquid
• Konzentration: 1.0 M in THF
• Dichte: 0.88 g/mL at 25 °C
• SMILES String: C[Si](C)(C)Cl
• InChI: 1S/C3H9ClSi/c1-5(2,3)4/h1-3H3
• InChIKey: IJOOHPMOJXWVHK-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Chlorotrimethylsilane (TMSCl) is a silylating agent employed in the silylation of alcohols, amines, carboxylic acids, thiols, and other functional groups. Silyl group serves as a protecting group for these original functional groups.

Anwendung

Chlorotrimethylsilane (TMSCl) can be used as a reagent:

• To synthesize allenylsilane via carbolithiation of conjugated enynes with aryllithium.
• In the reductive coupling of aldehydes and ketones to produce corresponding 1,2 diols in the presence of zirconocene dichloride and magnesium.
• To prepare 4,4′-bis(trimethylsilyl)bicyclohexyl-2,2′-diene from 1,3-cyclohexadiene by reductive disilylation reaction.

Sicherheitshinweise

• Piktogramme: GHS02,GHS08,GHS05,GHS07
• Signalwort: Danger
• H-Sätze: H225,H302,H314,H335,H351
• P-Sätze: P201 - P210 - P233 - P261 - P280 - P370 + P378
• Gefahreneinstufungen: Acute Tox. 4 Oral - Carc. 2 - Flam. Liq. 2 - Skin Corr. 1A - STOT SE 3
• Zielorgane: Respiratory system
• Zusätzliche Gefahrenhinweise: EUH014,EUH019
• Lagerklassenschlüssel: 3 - Flammable liquids
• WGK: WGK 1
• Flammpunkt (°F): -4.0 °F - closed cup
• Flammpunkt (°C): -20 °C - closed cup
• Persönliche Schutzausrüstung: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter