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Merck

GABRA1

gamma-aminobutyric acid (GABA) A receptor, alpha 1

Synonyme:
ECA4, EJM, EJM5
Spezies:
UniProtKB-ID:
Gen-ID:
  • Human(2554) Summary: This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(14394) gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1
  • Rat(29705) gamma-aminobutyric acid (GABA) A receptor, alpha 1
  • Zebrafish(768183) gamma-aminobutyric acid (GABA) A receptor, alpha 1
  • dog(489143) gamma-aminobutyric acid (GABA) A receptor, alpha 1
  • domestic cat(100286792) gamma-aminobutyric acid (GABA) A receptor, alpha 1
  • chicken(374214) gamma-aminobutyric acid (GABA) A receptor, alpha 1
  • cow(780973) gamma-aminobutyric acid (GABA) A receptor, alpha 1
  • sheep(101117759) gamma-aminobutyric acid (GABA) A receptor, alpha 1
  • naked mole-rat(101719179) gamma-aminobutyric acid (GABA) A receptor, alpha 1
  • domestic guinea pig(100721626) gamma-aminobutyric acid (GABA) A receptor, alpha 1

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Small Molecule - Agonist

Produktnummer
Beschreibung
Spezies
Gaboxadol -hydrochlorid, solid, ≥98% (HPLC),
Spezies
human
Muscimol hydrobromide, ≥98% (HPLC), solid,
Spezies
human
Isoguvacine hydrochloride, solid,
Spezies
human
Piperidine-4-sulfonic acid, ,
Spezies
human
Meprobamate solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Spezies
human

Small Molecule - Allosteric Modulator

Produktnummer
Beschreibung
Spezies
Zolpidem solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Spezies
human
Zaleplon solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Spezies
human
Dehydroisoandrosteron-3-Sulfat Natriumsalz Dihydrat, ≥93% (TLC), powder,
Spezies
human
3α,21-Dihydroxy-5α-pregnan-20-one, ≥95%,
Spezies
human
trans-Dehydroandrosteron, ≥99%,
Spezies
human, rat

Small Molecule - Antagonist

Produktnummer
Beschreibung
Spezies
Norfloxacin, analytical standard, ≥98% (TLC),
Spezies
rat, human
Ofloxacin, fluoroquinolone antibiotic,
Spezies
rat, human
Ciprofloxacin, ≥98% (HPLC),
Spezies
rat, human
Etiocholan-3α-ol-17-on, ,
Spezies
human, rat
Ro 15-4513, solid,
Spezies
rat, human

Antibodies

Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Anti-GABA in Kaninchen hergestellte Antikörper, affinity isolated antibody, buffered aqueous solution,
Speziesreaktivität
drosophila, rat, wide range
Anwendung
dot blot
immunohistochemistry
Anti-GABA-Antikörper, serum, Chemicon®,
Speziesreaktivität
all, rat
Anwendung
ELISA
immunohistochemistry
Monoclonal Anti-GABA antibody produced in mouse, clone GB-69, ascites fluid,
Speziesreaktivität
wide range
Anwendung
ELISA
dot blot

immunofluorescence

immunohistochemistry
Anti-GABA-A-Rezeptor-α-1-Ketten-Antikörper, NT, Klon BD24, clone BD24, Chemicon®, from mouse,
Speziesreaktivität
avian, bovine, human, pig
Anwendung
immunohistochemistry
immunoprecipitation (IP)

western blot
Anti-GABA A-Rezeptor β2/3-Antikörper, clone 62-3G1, Upstate®, from mouse,
Speziesreaktivität
bovine, human, rat
Anwendung
immunohistochemistry
immunoprecipitation (IP)

western blot

Small Molecule - Inhibitor

Produktnummer
Beschreibung
Spezies
2,6-Dimethylphenol, 99%,
Spezies
human
2-Isopropylphenol, ≥98%, FG,
Spezies
human
1,3-Diisopropylbenzol, 96%,
Spezies
human
2,6-Xylenol, ≥99%, FG,
Spezies
human
Amentoflavon, ≥98.0% (HPLC),
Spezies
human

Small Molecule - Ligand

Produktnummer
Beschreibung
Spezies
Ethyl alcohol, Pure, 200 proof, for molecular biology,
Spezies
human
Etomidat, >98% (HPLC), powder,
Spezies
human
Flumazenil, >99% (HPLC), solid,
Spezies
rat, human
Carbamazepin, powder,
Spezies
rat, human
2-Brom-2-chlor-1,1,1-trifluorethan, ≥99%,
Spezies
human

Small Molecule - Mixed Agonist/Antagonist

Produktnummer
Beschreibung
Spezies
Phenol -Lösung, BioReagent, Equilibrated with 10 mM Tris HCl, pH 8.0, 1 mM EDTA, for molecular biology,
Spezies
human
Phenol -Lösung, BioReagent, Saturated with 0.01 M citrate buffer, pH 4.3 ± 0.2, for molecular biology,
Spezies
human
Phenol, ≥99%,
Spezies
human
2,4-Di-tert.-butylphenol, 99%,
Spezies
human
2,6-Dimethoxyphenol, 99%,
Spezies
human

esiRNA

Produktnummer
Beschreibung
Spezies
MISSION® esiRNA, targeting human GABRA1,
Spezies
human
MISSION® esiRNA, targeting mouse Gabra1,
Spezies
mouse