- Highly enantioselective conjugate addition of nitromethane to chalcones using bifunctional cinchona organocatalysts.
Highly enantioselective conjugate addition of nitromethane to chalcones using bifunctional cinchona organocatalysts.
Organic letters (2005-05-07)
Benedek Vakulya, Szilárd Varga, Antal Csámpai, Tibor Soós
PMID15876031
RESUMO
Cinchona alkaloid-derived chiral bifunctional thiourea organocatalysts were synthesized and applied in the Michael addition between nitromethane and chalcones with high ee and chemical yields.
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Sigma-Aldrich
N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8a,9S)-6′-methoxy-9-cinchonanyl]thiourea, 90%
Sigma-Aldrich
N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8a,9S)-10,11-dihydro-6′-methoxy-9-cinchonanyl]thiourea, 90%