1670207

Tolcapone

United States Pharmacopeia (USP) Reference Standard

• Sinônimo(s): 3,4-Dihydroxy-4′-methyl-5-nitrobenzophenone, Ro 40-7592
• Fórmula empírica (Notação de Hill): C₁₄H₁₁NO₅
• Número CAS: 134308-13-7
• Peso molecular: 273.24
• Número MDL: MFCD00866569
• Código UNSPSC: 41116107
• ID de substância PubChem: 329751344
• NACRES: NA.24

Propriedades

• grau: pharmaceutical primary standard
• família API: tolcapone
• fabricante/nome comercial: USP
• aplicação(ões): pharmaceutical (small molecule)
• formato: neat
• cadeia de caracteres SMILES: Cc1ccc(cc1)C(=O)c2cc(O)c(O)c(c2)[N+]([O-])=O
• InChI: 1S/C14H11NO5/c1-8-2-4-9(5-3-8)13(17)10-6-11(15(19)20)14(18)12(16)7-10/h2-7,16,18H,1H3
• chave InChI: MIQPIUSUKVNLNT-UHFFFAOYSA-N
• Informações sobre genes: human ... COMT(1312)

Descrição

Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Tolcapone USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Tolcapone Tablets

Ações bioquímicas/fisiológicas

Tolcapone is an orally active catechol-O-methyltransferase (COMT) inhibitor. It inhibits both central and peripheral COMT. Tolcapone crosses the blood-brain barrier, and has been used for L-DOPA adjunct therapy in the treatment of Parkinson′s Disease.

Nota de análise

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Outras notas

Sales restrictions may apply.

Informações de segurança

• Pictogramas: GHS09
• Palavra indicadora: Warning
• Frases de perigo: H400
• Declarações de precaução: P273 - P391 - P501
• Classificações de perigo: Aquatic Acute 1
• Código de classe de armazenamento: 11 - Combustible Solids
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable