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Documentos Principais

1491004

USP

Oxytetracycline

United States Pharmacopeia (USP) Reference Standard

Sinônimo(s):

Oxytetracycline dihydrate

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About This Item

Fórmula empírica (Notação de Hill):
C22H24N2O9 · 2H2O
Número CAS:
Peso molecular:
496.46
Número CE:
Número MDL:
Código UNSPSC:
41116107
ID de substância PubChem:
NACRES:
NA.24

grau

pharmaceutical primary standard

família API

oxytetracycline

fabricante/nome comercial

USP

aplicação(ões)

pharmaceutical (small molecule)

Formato

neat

cadeia de caracteres SMILES

O.[H][C@@]12[C@@H](O)[C@@]3([H])C(C(=O)c4c(O)cccc4[C@@]3(C)O)=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)C

InChI

1S/C22H24N2O9.H2O/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29;/h4-6,12-14,17,25,27-29,32-33H,1-3H3,(H2,23,31);1H2/t12-,13-,14+,17+,21-,22+;/m1./s1

chave InChI

IBZHEBHGZFICKS-IFLJXUKPSA-N

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Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Oxytetracycline USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Oxytetracycline Hydrochloride
  • Oxytetracycline Injection
  • Oxytetracycline Tablets
  • Oxytetracycline for Injection
  • Oxytetracycline Hydrochloride Capsules
  • Oxytetracycline Hydrochloride Soluble Powder

Ações bioquímicas/fisiológicas

Antibiotic produced by Streptomyces rimosus.
Mode of Action: Inhibits protein synthesis (elongation) by preventing binding of aminoacyl-tRNA to the 30S subunit.
Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
Mode of Resistance: Active efflux, ribosome protection, tetracycline inactivation.

Nota de análise

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Outras notas

This product is part of USP Biologics Program.
Sales restrictions may apply.

Pictogramas

Health hazardEnvironment

Palavra indicadora

Warning

Frases de perigo

Classificações de perigo

Aquatic Chronic 2 - Repr. 2

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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Certificados de análise (COA)

Lot/Batch Number

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Hrvoje Petković et al.
Microbiology and molecular biology reviews : MMBR, 70(3), 704-728 (2006-09-09)
From a genetic standpoint, Streptomyces rimosus is arguably the best-characterized industrial streptomycete as the producer of oxytetracycline and other tetracycline antibiotics. Although resistance to these antibiotics has reduced their clinical use in recent years, tetracyclines have an increasing role in
Support vector regression for determination of component of compound oxytetracycline powder on near-infrared spectroscopy.
Tingting Zou et al.
Analytical biochemistry, 355(1), 1-7 (2006-05-26)
Extralabel use of oxytetracycline.
T Martin-Jimenez et al.
Journal of the American Veterinary Medical Association, 211(1), 42-44 (1997-07-01)
Lauren B Pickens et al.
The Journal of biological chemistry, 285(36), 27509-27515 (2010-06-05)
Oxytetracycline (OTC) is a broad-spectrum antibiotic that acts by inhibiting protein synthesis in bacteria. It is an important member of the bacterial aromatic polyketide family, which is a structurally diverse class of natural products. OTC is synthesized by a type
Shin-Young Park et al.
Journal of biomedical materials research. Part A, 103(1), 38-47 (2014-03-13)
Peri-implantitis is a chronic inflammatory process with advanced bone loss and impaired healing potential. For peri-implantitis treatment, tissue engineering can be applied to enhance bone regeneration of peri-implant defects. This study aimed to evaluate ex vivo bone morphogenetic protein 2

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