1443500

Miconazole nitrate

United States Pharmacopeia (USP) Reference Standard

• Sinônimo(s): (±)-Miconazole nitrate salt, 1-(2,4-Dichloro-β-[(2,4-dichlorobenzyl)oxy]phenethyl)imidazole
• Fórmula empírica (Notação de Hill): C₁₈H₁₄Cl₄N₂O · HNO₃
• Número CAS: 22832-87-7
• Peso molecular: 479.14
• Número MDL: MFCD00058161
• Código UNSPSC: 41116107
• ID de substância PubChem: 329750464
• NACRES: NA.24

Propriedades

• grau: pharmaceutical primary standard
• família API: miconazole
• fabricante/nome comercial: USP
• aplicação(ões): pharmaceutical (small molecule)
• Formato: neat
• cadeia de caracteres SMILES: ClC1=CC(Cl)=CC=C1C(OCC2=CC=C(Cl)C=C2Cl)CN3C=CN=C3.[O-][N+](O)=O
• InChI: 1S/C18H14Cl4N2O.HNO3/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22;2-1(3)4/h1-8,11,18H,9-10H2;(H,2,3,4)
• chave InChI: MCCACAIVAXEFAL-UHFFFAOYSA-N

Descrição

Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Miconazole nitrate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Miconazole Nitrate Cream
• Miconazole Nitrate Topical Powder
• Miconazole Nitrate Vaginal Suppositories

Ações bioquímicas/fisiológicas

Miconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary for ergosterol biosynthesis. The inhibition of ergosterol results in increased cellular permeability causing leakage of cellular contents. Miconazole may also inhibit endogenous respiration, interact with phospholipids in the cell membrane, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and interfere with triglyceride and phospholipid biosynthesis.

Nota de análise

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Outras notas

Sales restrictions may apply.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302,H317
• Declarações de precaução: P280 - P301 + P312 + P330 - P302 + P352
• Classificações de perigo: Acute Tox. 4 Oral - Skin Sens. 1
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable