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1324002

USP

Hydroquinone

United States Pharmacopeia (USP) Reference Standard

Sinônimo(s):

1,4-Benzenediol, 1,4-Dihydroxybenzene, HQ

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About This Item

Fórmula linear:
C6H4-1,4-(OH)2
Número CAS:
123-31-9
Peso molecular:
110.11
Beilstein:
605970
Número MDL:
MFCD00002339
Código UNSPSC:
41116107
ID de substância PubChem:
329750111
NACRES:
NA.24

grau

pharmaceutical primary standard

densidade de vapor

3.81 (vs air)

pressão de vapor

1 mmHg ( 132 °C)

família API

hydroquinone

temperatura de autoignição

930 °F

fabricante/nome comercial

USP

p.e.

285 °C (lit.)

pf

172-175 °C (lit.)

aplicação(ões)

pharmaceutical (small molecule)

Formato

neat

cadeia de caracteres SMILES

Oc1ccc(O)cc1

InChI

1S/C6H6O2/c7-5-1-2-6(8)4-3-5/h1-4,7-8H

chave InChI

QIGBRXMKCJKVMJ-UHFFFAOYSA-N

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Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Hydroquinone USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.
Also, for use with USP monographs such as:
  • Hydroquinone Cream
  • Hydroquinone Topical Solution

Nota de análise

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Outras notas

Sales restrictions may apply.

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Palavra indicadora

Danger

Classificações de perigo

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Eye Dam. 1 - Muta. 2 - Skin Sens. 1B

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

329.0 °F - closed cup

Ponto de fulgor (°C)

165 °C - closed cup

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Mekhala Chandra et al.
Acta dermato-venereologica, 92(3), 232-235 (2011-10-18)
Post-inflammatory hyperpigmentation after acne can be as troublesome as the acne itself. Hydroquinone, a tyrosinase inhibitor, in a 4% cream can be used safely twice daily for up to 6 months to treat post-inflammatory hyperpigmentation. The efficacy of this treatment
Jacob Levitt
Journal of the American Academy of Dermatology, 57(5), 854-872 (2007-05-01)
Recently, the US Food and Drug Administration proposed a ban on over-the-counter hydroquinone mainly on the basis of high absorption, reports of exogenous ochronosis in humans, and murine hepatic adenomas, renal adenomas, and leukemia with large doses over extended time
J J Nordlund et al.
Journal of the European Academy of Dermatology and Venereology : JEADV, 20(7), 781-787 (2006-08-11)
Hydroquinone is one of the most effective molecules for the treatment of hyperpigmentary disorders, with over 40 years of efficacy and safety data. Concerns over its safety have been raised because of the fact that it is a derivative of
Sara M Belchik et al.
Drug metabolism reviews, 43(2), 307-316 (2011-03-24)
Glutathione transferases (GSTs) are best known for transferring glutathione (GSH) to hydrophobic organic compounds, making the conjugates more soluble. However, the omega-class GSTs of animals and the lambda-class GSTs and dehydroascorbate reductases (DHARs) of plants have little or no activity
Douglas McGregor
Critical reviews in toxicology, 37(10), 887-914 (2007-11-21)
The toxicology of hydroquinone has been reviewed on a number of previous occasions. This review targets its potential for carcinogenicity and possible modes of carcinogenic action. The evaluation made by IARC (1999) of its carcinogenic risk to humans was that
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