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1205003

USP

Diltiazem hydrochloride

United States Pharmacopeia (USP) Reference Standard

Sinônimo(s):

(+)-cis-Diltiazem hydrochloride, (2S,3S)-(+)-cis-3-Acetoxy-5-(2-dimethylaminoethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride, CRD-401

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About This Item

Fórmula empírica (Notação de Hill):
C22H26N2O4S · HCl
Número CAS:
33286-22-5
Peso molecular:
450.98
Beilstein:
4228706
Número MDL:
MFCD00069252
Código UNSPSC:
41116107
ID de substância PubChem:
329749607
NACRES:
NA.24

grau

pharmaceutical primary standard

família API

diltiazem

fabricante/nome comercial

USP

aplicação(ões)

pharmaceutical (small molecule)

Formato

neat

cadeia de caracteres SMILES

Cl.COc1ccc(cc1)[C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O

InChI

1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1

chave InChI

HDRXZJPWHTXQRI-BHDTVMLSSA-N

Informações sobre genes

human ... CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779)

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Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Nota de análise

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Outras notas

Sales restrictions may apply.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H302

Declarações de precaução

P301 + P312 + P330

Classificações de perigo

Acute Tox. 4 Oral

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number

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Diltiazem hydrochloride.
B F McGraw
Drug intelligence & clinical pharmacy, 16(5), 366-370 (1982-05-01)
[Diltiazem hydrochloride: synthetic and pharmacological studies and development].
K Abe et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 108(8), 716-732 (1988-08-01)
Hossein Gandomkar et al.
Diseases of the colon and rectum, 58(2), 228-234 (2015-01-15)
The aim of this study is to evaluate the effectiveness and complications associated with combined topical diltiazem cream and botulinum toxin A injection versus partial lateral internal sphincterotomy in chronic anal fissure. This study is a parallel, randomized controlled trial
Takeshi Ogura et al.
Acta neurochirurgica. Supplement, 120, 47-50 (2014-11-05)
This study evaluated the effect of diltiazem, a calcium antagonist, on sympathetic activity in patients with aneurysmal subarachnoid hemorrhage (SAH) during the hyperacute stage. Of patients with aneurysmal SAH who underwent aneurysm repair between August 2008 and June 2011, 119
B J McAuley et al.
Pharmacotherapy, 2(3), 121-133 (1982-05-01)
Diltiazem, a calcium channel blocking agent, has potent cardiovascular effects that are directly related to its influence on vascular smooth muscle, ventricular myocardium, and specialized conducting tissue. It causes coronary and peripheral vasodilation, has a negative chronotropic and dromotropic effect
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